Publications using Qkine HGF & PDGF/VEGF family proteins

HGF | VEGF

HGF family

PDGF/VEGF family

Hepatocyte growth factor (HGF), also known as Scatter factor, acts as a multifunctional cytokine on cells including endothelial and epithelial cells, melanocytes, and keratinocytes. HGF is now recognized as a key player in mediating protection against various inflammatory and autoimmune diseases. Qkine HGF range includes human, bovine and porcine HGF (NK1) a potent naturally occurring isoform of HGF.

The PDGF family is composed of PDGF-A, PDGF-B, PDGF-C, and PDGF-D. These four PDGFs remain inactive in their monomeric forms. Upon activation, PDGFs interact with protein tyrosine kinase receptors known as PDGF receptor-α and -β. The PDGF superfamily also includes VEGFs, the VEGF/PDGF super gene family of growth factors is characterized by the presence of eight conserved cysteine residues forming disulfide linked dimers. They play essential roles in controlling cell survival, proliferation, and migration both during development and the process of wound healing.

HGF

Lyer, D. P. et al. mTOR activity paces human blastocyst stage developmental progression
Cell (2024)

DOI: doi: 10.1016/j.cell.2024.08.048

From the lab of Aydan Bulut-Karsliogl, Department of Genome Regulation, Max Planck Institute for Molecular Genetics

Used:
FGF2-G3 (Qk053)
HGF (NK1) (Qk013)
FGF-10 (Qk003)

VEGF

Azami, T. et al. STAT3 signalling enhances tissue expansion during postimplantation mouse development
bioRxiv preprint (2024)

doi: https://doi.org/10.1101/2024.10.11.617785

From the lab of Dr Jennifer Nichols, University of Cambridge

Used:
activin A (Qk001)
BMP-4 (Qk038)
VEGF165 (Qk048)
SCF (Qk078)

Zambaldi, V. et al. De novo design of high-affinity protein binders with AlphaProteo
arXiv (2024)

DOI: https://doi.org/10.48550/arXiv.2409.08022

Used:
VEGF (Qk048)