Recombinant Gremlin-1 protein, a BMP inhibitor, is optimized for exceptionally high purity production from E.coli. Animal-derived component free for defined media. Gremlin-1 can substitute for Noggin in several embryonic and induced-pluripotent stem cell and organoid culture systems including intestinal, liver, pancreatic and cancer or tumor organoids.
Optimized human recombinant R-spondin 1 (Qk006 RSPO1) was developed during a project co-funded by Innovate UK. Data from collaborators at Cold Spring Harbor lab show succesful replacement of R-spondin conditioned media with recombinant R-spondin-1 to support scaling of organoid applications. Qk006 is carrier protein and animal-derived component free. For samples or bulk pricing, please email us orders@qkine.com
Exciting new cellular stress biomarker Growth/differentiation factor 15 (GDF15): we guarantee absolutely no contamination from related TGF beta family proteins, which solves a huge problem for researchers in this field (Olsen,2017). Manufactured to our rigorous standard and tested in a well-characterized SMAD2/3 activation assay to confirm no SMAD signalling.
R-spondin-1 replaces conditioned media in pancreatic tumor organoid culture – data from Tuveson Laboratory, Cold Spring Harbor Lab
Order online and upload your PO or pay by credit card, or email your PO to orders@qkine.com. For bulk orders and stock reservation email or phone +44 (0) 1223 491486 / US toll free 1-866 877 2185. We don’t actually deliver everywhere by bike – unless you are in the middle of Cambridge, UK! We do ship for free to all US and European labs and biotechs. If you are outside this area contact us and we’ll let you know shipping costs (always reasonable).
We use proprietary refolding technologies and protein purification techniques developed at the University of Cambridge to produce high purity, animal-derived component free growth factors and cytokines. By solving scientific challenges such as structural heterogeneity, poor stability and solubility and spurious interactions with other biomolecules,we provide you more reliable tools for stem cell and organoid culture.