Growth factors for cultivated meat, fish, fat and dairy

Qkine is committed to manufacturing enhanced-quality bioactive proteins to improve scientific outcomes and reproducibility. We provide a complete portfolio of animal-free and carrier protein-free growth factors for cultivated meat, fish and dairy.

Growth factors for cellular agriculture including cultivated meat, fish, fat and dairy

Cellular agriculture has the potential to transform food production and impact the health and well-being of future generations. Immediate priorities for cultivated meat and dairy process development include optimizing serum-free cell culture media to support cell expansion and maturation stages in bioreactor conditions.

Replacing animal-derived components, particularly fetal bovine serum (FBS), is essential for consistent performance, to remove the risk of contamination from viruses or prions and opens opportunities for fine-tuning of culture conditions.

Growth factors are critical components of cell culture media and provide a carefully orchestrated set of biochemical signals to control cell growth and fate. High purity, animal-free and optimized growth factors produced in an efficient microbial fermentation process provide the most reliable solution for cultivated meat and cellular agriculture.

We provide extensive CoO, CoA and animal-free (AOF/ADCF) documentation, bulk pricing, stock reservation service and opportunities for collaboration to support this important field. Please contact us to discuss further.

Animal origin-free recombinant proteins for cultivated meat

Species-specific growth factors for cellular agriculture including cultivated meat, fish, fat and dairy

Food Standards Agency’s from around the world have continued support of alternative proteins and food innovation. In-depth reviews of current novel food frameworks, updating dossier submission platforms and updating food guidelines have resulted in further promise in this field.

With feedback from this progression and new guidelines from the FDA (Food and Drug Administration) in the US and UK Food Standards Agency (FSA), it is clear cultivated meat companies are being strongly advised to use growth factors with protein sequences that are 100% homologous to the species of animal they are cultivating in the production process. Growth factors from the target species also aid consumer acceptance and species-specific activity as well as regulatory considerations.

Qkine is dedicated to supporting the cellular agriculture industry by manufacturing high-purity and bioactive growth factors that are species-specific to cultivated cultures including porcine, bovine and fish.

Frequently used growth factors where the amino acid sequence is 100% conserved between human, bovine, and porcine species
CodeProduct nameSpeciesHuman to porcineHuman to bovineComments
Qk001Activin AHuman100%100%Human sequence identical to porcine and bovine Activin A
Qk047IGF-1Human100%100%Human sequence identical to porcine and bovine IGF-1
Qk045NRG-1Human100%100%Human sequence identical to porcine and bovine NRG-1
Qk010TGF-β1 PLUSHuman100%100%Human sequence identical to porcine and bovine TGF-β1
Qk072TGF-β2Human100%100%Human sequence identical to porcine and bovine TGF-β2
Frequently used growth factors where the amino acid sequence is similar but not 100% conserved when comparing human, bovine and porcine species
CodeProduct nameSpeciesHuman to porcineHuman to bovineComments
Qk011EGFHuman~85%Porcine EGF available (Qk064)
Bovine EGF coming soon (enquire for more information)
Qk025FGF-2
(145 aa)
Human~99%~99%Bovine/porcine FGF-2 (145 aa) available (Qk040)
Qk027FGF-2
(154 aa)
Human~99%~99%Bovine/porcine FGF-2 (154 aa) available (Qk056)
Qk013HGF (NK1)Human~95%~93%Porcine HGF (NK1) available (Qk061)
Bovine HGF (NK1) available (Qk060)
Qk036LIFHuman87%88%Porcine and bovine LIF coming soon
Qk044PDGF-BBHuman~95%91%Porcine PDGF-BB coming soon
Qk054TGF-β3Human~98%~99%Porcine TGF-β3 available (Qk084)
Bovine TGF-β3 coming soon

Growth factor discovery kits for cultivated meat, fish, fat and dairy

Qkine Discovery pack 1
FGF-2 species-specific discovery kit

For rapid testing of multiple species FGF-2 and thermostable FGF-2 to replace human proteins in cell cultivated meat.

Thermostable FGF-2 discovery kit Qk502
Thermostable FGF-2 discovery kit

For rapid testing of FGF-2 with thermostable FGF-2  protein, to determine whether the short half-life of FGF-2 is impacting cell fate.

B8 media discovery kit Qk503
B8 media discovery kit

For current hiPSC media comparison with B8 media to see if your cells can be maintained as efficiently while giving you the weekends off.

Beefy9 media discovery kit Qk504
Beefy9 media discovery kit

For rapid testing of Beefy-9 against current serum-free bovine stem cell maintenance media to evaluate whether your bovine satellite cells can be expanded more efficiently.

Serum-free media optimization kit Qk505
Serum-free media optimization kit

For rapid optimization of your media to become entirely serum-free. This kit contains 7 growth factors commonly used in a variety of serum-free media. Use it to optimize media for your cells to fully define your media.

All our recombinant proteins are animal-free
and come with Bioactivity. Guaranteed.

Featured resources for cultivated meat, fish, fat and dairy

Application Note

Cultivated meat application note

Species-specific and optimized growth factors for the production of bovine and porcine cultivated meat and fat

Blog

Thermostable FGF2-G3 for serum-free media optimization

Considerations for the use of high-purity recombinant growth factors in cellular agriculture applications

Technote

TGF beta 1 (AOF/ADCF)

First animal-free TGF beta 1 – scalable microbial manufacture. Qkine TGF-ß1 PLUS has higher bioactivity than alternative suppliers

Product focus

Animal-free cell culture with HGF natural isoform NK1

The NK1 isoform is the smallest naturally occurring splice variant of HGF, it comprises the HGF N-terminal and first kringle domain. Qkine HGF NK1 is also completely animal-free (AOF), making it suitable for chemically defined media and reproducible scale-up. This isoform promotes efficient differentiation of human iPSCs at just 10 ng/ml.

Contact our expert team

Our dedicated team of stem cell specialists is available to answer any queries and to give expert support when required.

Animal-free growth factors for cellular agriculture

Our science team is here to help, please contact us if you have any questions.