Human Activin A protein is a member of the TGFβ superfamily of growth factors involved in stem cell differentiation and maintenance, regulation of embryogenesis, development of the reproductive system, wound healing and regulation of immune responses. The activity of Activin A protein is regulated by the high-affinity inhibitor, follistatin1, and inhibins.
Activins are disulfide-linked homo- and heterodimers of four inhibin β chains. The best characterized are Activin A and Activin B, homodimers of inhibin βA and inhibin βB respectively. Activins, like all other members in the TGF-β superfamily, are synthesized as larger precursors consisting of an N-terminal signal peptide, a pro-domain of 250–350 residues and a highly conserved mature domain. The pro-domain, which is cleaved off in the mature protein, has important roles in the biosynthesis, stabilization, transportation and signalling of the growth factors2.
Recombinant Activin A is used for maintenance of pluripotency in many human induced-pluripotent stem cell and human embryonic stem cell lines3, and to induce stem cell differentiation into endoderm4 and other cell fates.
Our recombinant Activin A protein has been extensively validated and benchmarked with other suppliers’ proteins in stem cell culture and other assays. View the results of this analysis and a commentary by Qkine’s founder Marko Hyvönen.