@article{pmid32034154,
title = {IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche},
author = {S E Wamaitha and K J Grybel and G Alanis-Lobato and C Gerri and S Ogushi and A McCarthy and S K Mahadevaiah and L Healy and R A Lea and M Molina-Arcas and L G Devito and K Elder and P Snell and L Christie and J Downward and J M A Turner and K K Niakan},
doi = {10.1038/s41467-020-14629-x},
year = {2020},
date = {2020-01-01},
journal = {Nat Commun},
volume = {11},
number = {1},
pages = {764},
keywords = {Activin-A},
pubstate = {published},
tppubtype = {article}
}

@article{pmid32398665,
title = {Ŧhe transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of ŦGF-beta in human PSCs},
author = {I Zorzan and M Pellegrini and M Arboit and D Incarnato and M Maldotti and M Forcato and G M Tagliazucchi and E Carbognin and M Montagner and S Oliviero and G Martello},
doi = {10.1038/s41467-020-16205-9},
year = {2020},
date = {2020-01-01},
journal = {Nat Commun},
volume = {11},
number = {1},
pages = {2364},
abstract = {Human pluripotent stem cells (hPSCs) have the capacity to give rise to all differentiated cells of the adult. TGF-beta is used routinely for expansion of conventional hPSCs as flat epithelial colonies expressing the transcription factors POU5F1/OCT4, NANOG, SOX2. Here we report a global analysis of the transcriptional programme controlled by TGF-beta followed by an unbiased gain-of-function screening in multiple hPSC lines to identify factors mediating TGF-beta activity. We identify a quartet of transcriptional regulators promoting hPSC self-renewal including ZNF398, a human-specific mediator of pluripotency and epithelial character in hPSCs. Mechanistically, ZNF398 binds active promoters and enhancers together with SMAD3 and the histone acetyltransferase EP300, enabling transcription of TGF-beta targets. In the context of somatic cell reprogramming, inhibition of ZNF398 abolishes activation of pluripotency and epithelial genes and colony formation. Our findings have clear implications for the generation of bona fide hPSCs for regenerative medicine.},
keywords = {Activin-A, bFGF, FGF2},
pubstate = {published},
tppubtype = {article}
}

@article{pmid31491390,
title = {Evaluation of Stuart et al.: Đistinct Molecular Ŧrajectories Converge to Induce Naive Pluripotency},
author = {M Stadtfeld},
year = {2019},
date = {2019-01-01},
journal = {Cell Stem Cell},
volume = {25},
number = {3},
pages = {297--298},
abstract = {An example of the peer review process for "Distinct molecular trajectories converge to induce naive pluripotency" (Stuart et al., 2019) is presented here.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{pmid31422912,
title = {Đistinct Molecular Ŧrajectories Converge to Induce Naive Pluripotency},
author = {H T Stuart and G G Stirparo and T Lohoff and L E Bates and M Kinoshita and C Y Lim and E J Sousa and K Maskalenka and A Radzisheuskaya and A A Malcolm and M R P Alves and R L Lloyd and S Nestorowa and P Humphreys and W Mansfield and W Reik and P Bertone and J Nichols and B G?ttgens and J C R Silva},
doi = {10.1016/j.stem.2019.07.009},
year = {2019},
date = {2019-01-01},
journal = {Cell Stem Cell},
volume = {25},
number = {3},
pages = {388--406},
abstract = {Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are questions of wide interest. Here we show that acquisition of naive pluripotency can follow transcriptionally and mechanistically distinct routes. Starting from post-implantation epiblast stem cells (EpiSCs), one route advances through a mesodermal state prior to naive pluripotency induction, whereas another transiently resembles the early inner cell mass and correspondingly gains greater developmental potency. These routes utilize distinct signaling networks and transcription factors but subsequently converge on the same naive endpoint, showing surprising flexibility in mechanisms underlying identity transitions and suggesting that naive pluripotency is a multidimensional attractor state. These route differences are reconciled by precise expression of Oct4 as a unifying, essential, and sufficient feature. We propose that fine-tuned regulation of this "transition factor" underpins multidimensional access to naive pluripotency, offering a conceptual framework for understanding cell identity transitions.},
keywords = {Activin-A, bFGF, FGF2},
pubstate = {published},
tppubtype = {article}
}

@article{SJI2018,
title = {Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell-Derived Hepatocytes for Cell-Based Therapy.},
author = {Blackford SJI, Ng SS, Segal JM, King AJF, Austin AL, Kent D, Moore J, Sheldon M, Ilic D, Dhawan A, Mitry RR, Rashid ST},
doi = {10.1002/sctm.18-0084},
year = {2018},
date = {2018-11-19},
journal = {Stem Cells Transl Med},
keywords = {Activin-A, cGMP},
pubstate = {published},
tppubtype = {article}
}