coming soon

recombinant human/bovine/porcine IGF-1 protein (Qk047)

Human IGF-1, insulin-like growth factor 1, protein is often used in the maintenance of human pluripotent stem cells¹

Highly pure and bioactive 9 kDa IGR-1 protein monomer, animal-free (AF) and carrier-protein free (CF)

If you are interested in this protein and want to be alerted as soon as it is launched please let us know!

description
customer & collaborator data

summary

high purity human IGF-1 protein (Uniprot:P05019)
9 kDa
expressed in E. coli.
animal-free (AOF) and carrier protein-free.
manufactured in our Cambridge, UK laboratories
lyophilized from acetonitrile, TFA
resuspend in water at >100 µg/ml, prepare single use aliquots, add carrier protein if desired and store frozen at -20 oC or -80 oC

handling and storage FAQ

featured applications

maintenance of pluripotency in human iPSC
cell culture media optimisation and replacement of insulin in defined media

alternative protein names

Long R3 IGF-I, Insulin-like Growth Factor-I, Somatamedin C, IGF-IA

background references

1. Wang, Linlin, et al. ‘Self-Renewal of Human Embryonic Stem Cells Requires Insulin-like Growth Factor-1 Receptor and ERBB2 Receptor Signaling’. Blood, vol. 110, no. 12, Dec. 2007, pp. 4111–19.

2. Laron, Z. ‘Insulin-like Growth Factor 1 (IGF-1): A Growth Hormone’. Molecular Pathology, vol. 54, no. 5, Oct. 2001, pp. 311–16.

species reactivity

human

porcine (pig)

bovine (cow)

research areas

protein background

Insulin-like growth factor 1 (IGF-1) is a protein with a similar structure to insulin and is used frequently to replace or reduce the requirement for insulin in cell culture media. IGF-1 is a primary mediator of growth hormone (GH), with growth-promoting effects on most cells and tissues including skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, hematopoietic and lung.²IGF-I activates numerous signalling pathways, including PI3K/AKT and ERK1/2 signalling, through binding the IGF-I receptor.²

We welcome all feedback and specialist collaborator data on all our products. If you would like to provide application-specific feedback, please submit a review or contact our team support@qkine.com

Our products are for research use only and not for diagnostic or therapeutic use. Products are not for resale.

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