Protein by family

Activin proteins

Qkine is committed to manufacturing bioactive proteins of the highest quality to enhance scientific outcomes and improve reproducibility. Our stringent quality control procedures in place ensure your results are reliable and reproducible every time.  We couple this with unrivaled lot-to-lot consistency, ensuring every single batch meets the same quality standards as all previous ones, thereby reducing the need for batch testing.

Bone morphogenetic proteins and antagonists

Bone morphogenic proteins (BMPs) are members TGFβ family and are important regulators of tissue development and growth. Qkine BMP range includes BMP-2 and BMP-4 which are key regulators of embryogenesis and potent differentiation factors for embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). BMP antagonists are important regulators of BMP activity in development. Qkine BMP antagonist range includes mouse and human noggin and gremlin 1.

Colony stimulating factors

Colony-stimulating factors family, also known as hematopoietic growth factors, include granulocyte-macrophage-CSF (GM-CSF), macrophage colony formation CSF (M-CSF), granulocyte-CSF (G-CSF), and multi-CSF, which is also referred to as interleukin-3 (IL-3). These CSFs serve various functions such as promoting cell proliferation, facilitating cell maturation, and encouraging cell differentiation.

Cytokines

Epidermal growth factors

The Epidermal growth factor (EGF) family includes EGF and Neuregulins. EGF plays crucial roles in the regulation of cell proliferation, survival, differentiation, and migration. Epidermal growth factor (EGF) stimulates cell growth and differentiation by binding to its receptor, EGFR.

Extracellular matrix proteins

The extracellular matrix (ECM) consists of hundreds of different molecules and is the non-cellular component of tissues. Some of the major protein components of the ECM are collagen, fibronectin, elastin, laminin, proteoglycan, fibulins, vitronectin.

Fibroblast growth factors

Fibroblast growth factors (FGFs) are a family of 22 proteins (18 secreted proteins and 4 intracellular FGFs) involved in many developmental processes. Fibroblast Growth Factors stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. Qkine FGF portfolio includes many members of the FGF superfamily: FGF-1, FGF-2, FGF-4, FGF-7, FGF-8a, FGF-8b, FGF-9, FGF-10 and FGF-18.

Hepatocyte growth factors

Hepatocyte growth factor (HGF), also known as Scatter factor, acts as a multifunctional cytokine on cells including endothelial and epithelial cells, melanocytes, and keratinocytes. HGF is now recognized as a key player in mediating protection against various inflammatory and autoimmune diseases.

IGF family

The insulin-like growth factors (IGFs) are proteins with a similar structure to insulin. This family includes ligands and insulin, receptors and insulin receptor, and IGF-binding proteins. The insulin-like growth factor family plays important roles in differentiation, cellular metabolism, proliferation, apoptosis and transformation.

Interleukins

IL superfamily is a large group of cytokines, including proteins known as interleukins and interleukin receptors. Members of this superfamily play pivotal roles in diverse biological processes such as immunity, inflammation, and hematopoiesis. Subgroups within the interleukin superfamily include the IL-1, IL-6, IL-10, IL-12, and IL-17 subfamilies, along with additional interleukins and receptors.

Neurotrophin family

The Neurotrophin family includes Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin-3, and Neurotrophin-4. Functioning as growth factors, Neurotrophins play crucial roles in regulating the development, survival, and maintenance of neurons within both the central and peripheral nervous systems, thereby contributing significantly to neural plasticity and overall nervous system function.

Other growth factors

Growth factors are essential for stimulating cell growth, proliferation, differentiation, and migration. They act as signaling molecules, mediating cell-cell communication to regulate various cellular processes, including wound healing, tissue repair and development.

PDGF family

The PDGF family is composed of PDGF-A, PDGF-B, PDGF-C, and PDGF-D. These four PDGFs remain inactive in their monomeric forms. Upon activation, PDGFs interact with protein tyrosine kinase receptors known as PDGF receptor-α and -β.
PDGFs play essential roles in controlling cell survival, proliferation, and migration both during development and the process of wound healing.

R-spondin family

R-spondin family (RSPO) includes 4 secreted glycoproteins (R-spondin 1, R-spondin 2, R-spondin 3, R-spondin 4). Implicated in the activation and regulation of the Wnt signaling pathway, RSPO proteins contribute significantly to various biological processes throughout embryonic development, adult tissue maintenance, and the onset of disease. This family of secreted proteins is also used widely in organoid culture.

TGF-β superfamily

Members of the TGF-beta superfamily, such as activins, TGF-beta 1, TGF-beta 2, TGF-beta 3, GDF-5, GDF-15, GDNF, and BMPs, play crucial roles in governing various developmental and physiological processes. These proteins contribute to the regulation of fundamental cellular properties and vital cellular processes, such as cell growth, differentiation, proliferation, survival, apoptosis, morphogenesis, and tissue remodeling.