Publications

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018

2024

Bomin Ku, et al. ‘PRMT1 promotes pancreatic cancer development and resistance to chemotherapy’. Cell Reports Medicine (2024).

DOI: https://doi.org/10.1016/j.xcrm.2024.101461

From the lab of Dae-sik Lim, KAIST, Republic of Korea

Used:
R-Spondin 1 (Qk006)

Joycelyn Tan, et al. ‘Limited oxygen in standard cell culture alters metabolism and function of differentiated cells’. The Embo Journal (2024).

DOI: https://doi.org/10.1038/s44318-024-00084-7

From the lab of Daniel J. Fazakerley, University of Cambridge

Used:
Zebrafish FGF-2 (Qk002)
Human BMP-4 (Qk038)

Nanami Sato, Viviane S Rosa, Aly Makhlouf, et al. ‘Basal delamination during mouse gastrulation primes pluripotent cells for differentiation’. ScienceDirect (2024).

DOI: https://doi.org/10.1016/j.devcel.2024.03.008

From the lab of Marta Shahbazi, MRC Laboratory of Molecular Biology, Cambridge

Used:
Gremlin 1 (Qk015)

Sami Jalil, Timo Keskinen, et al. ‘Genetic and functional correction of argininosuccinate lyase deficiency using CRISPR adenine base editors’ AJHG (2024).

DOI: https://doi.org/10.1016/j.ajhg.2024.03.004

From the lab of Kirmo Wartiovaara, University of Helsinki

Used:
Activin A (Qk001)

Viviana Macarelli, Edward Harding, et al. ‘A short sequence targets transmembrane proteins to primary cilia.’ bioRxiv (2024).

DOI: https://doi.org/10.1101/2024.04.02.587776

From the lab of Florian Merkle, University of Cambridge

Used:
Human BDNF (Qk050)

Huanhuan Li et al. ‘Protocol for generating mouse morula-like cells resembling 8- to 16-cell stage embryo cells’ ScienceDirect (2024).

DOI: https://doi.org/10.1016/j.xpro.2024.102934

From the lab of Jose Silva, Guangzhou, China

Used:
Mouse LIF (Qk018)

Jan Żylicz, Karlien van Nerum, Anne Wenzel, Lidia Argemi Muntadas, et al. ‘Metabolic rewiring underpins human trophoblast induction.’ Preprint (2024).

DOI: https://doi.org/10.21203/rs.3.rs-3575549/v1

From the lab of Jan Żylicz, University of Copenhagen, Denmark

Used:
Human LIF (Qk036)
Human EGF (Qk011)

Shin, D., Kim, C.N., Ross, J., Frost, N.A., Sohal, V.S. et al. ‘Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders.’ Cell Stem Cell (2024).

DOI: https://doi.org/10.1016/j.stem.2024.01.010

From the lab of Tomasz Nowakowski, University of California, San Francisco

Used:
TGF-β3 (Qk054)

van Bree, N., Oppelt, A. et al. ‘Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing.’ bioRxiv (2024).

DOI: https://doi.org/10.1101/2024.02.21.578208

From the lab of Margareta Wilhelm, Karolinska Institutet

Used:
FGF2-G3 (Qk053)

Guo, M., Wu, J., Chen, C. et al. ‘Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously.’ Nat Commun (2024).

DOI: https://doi.org/10.1038/s41467-024-44969-x

From the lab of José Silva, Guangzhou Laboratory

Used:
Activin A (Qk001)
hLIF (Qk036)

Krammer, T. et al. ‘Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition’
Developmental Cell 59, 1940–1953

DOI: https://doi.org/10.1016/j.devcel.2024.04.021

From the labs of James Briscoe and Elly M. Tanaka, Francis Crick Institute and the Research Institute of Molecular Pathology (IMP) of Vienna

Used:
Murine LIF (Qk018)

Weatherbee, B.A.T., Weberling, A., Gantner, C.W. et al. ‘Distinct pathways drive anterior hypoblast specification in the implanting human embryo.’ Nat Cell Biol (2024).

DOI: https://doi.org/10.1038/s41556-024-01367-1

From the lab of Magdalena Zernicka-Goetz, University of Cambridge

Used:
Activin A (Qk001)

Lumibao, J. C., Okhovat, S. R., Peck, K. L., Lin, X., Lande, K., Yomtoubian, S., Ng, I., Tiriac, H., Lowy, A. M., Zou, J., & Engle, D. D. ‘The effect of extracellular matrix on the precision medicine utility of pancreatic cancer patient–derived organoids.’ JCI Insight (2024).

DOI: https://doi.org/10.1172/jci.insight.172419

From the lab of Dannielle Engle, Salk Institute for Biological Studies

Used:
Noggin (Qk034)
R-spondin 1 (Qk006)

Beltran-Rendon, C., Price, C. J. et al. ‘Modeling the selective growth advantage of genetically variant human pluripotent stem cells to identify opportunities for manufacturing process control.’ Cytotherapy (2024).

DOI: https://doi.org/10.1016/j.jcyt.2024.01.010

From the lab of Robert Thomas, Loughborough University

Used:
FGF2-G3 (Qk053)
TGF-β1 PLUS (Qk010)

Fejzo, M., Rocha, N., Cimino, I. et al. ‘GDF15 linked to maternal risk of nausea and vomiting during pregnancy.’ Nature (2024).

DOI: https://doi.org/10.1038/s41586-023-06921-9

From the lab of Stephen O’Rahilly, University of Cambridge

Used:
GDF-15 (Qk017)

2023

Stavish, D. et al. ‘Cytogenetic resource enables mechanistic resolution of changing trends in human pluripotent stem cell aberrations linked to feeder-free culture.’ Preprint (2023).

DOI: https://doi.org/10.1101/2023.09.21.558777

From the lab of Ivana Barbaric, University of Sheffield

Used:
FGF2-G3 (Qk053)

Arboit, M. et al. ‘KLF7 is a general inducer of human pluripotency.’ Preprint (2023).

DOI: https://doi.org/10.1101/2023.09.06.556189

From the lab of Elena Carbognin and Graziano Martello, University of Padua

Used:
FGF-2 (Qk002)
LIF (Qk036)

Agarwal, D. et al. ‘Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming.’ Npj Regen. Med. 8, 1–18 (2023).

DOI: https://doi.org/10.1038/s41536-023-00327-x

From the lab of Karl Wahlin, University of California San Diego

Used:
BDNF (Qk050)
GDNF (Qk051)

Militi, S., Nibhani, R., Jalali, M. & Pauklin. S. ‘RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling.’ Cell Rep. 42, 113146 (2023).

DOI: https://doi.org/10.1016/j.celrep.2023.113146

From the lab of Siim Pauklin, University of Oxford

Used:
Activin A (Qk001)

Andrés-San Román, J. A. et al. ‘CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia.’ Cell Rep. Methods 100597 (2023).

DOI: https://doi.org/10.1016/j.crmeth.2023.100597

From the lab of Luis M. Escudero, University of Sevilla

Used:
LIF (Qk018)

Boikova, A. et al. ‘A transient modified mRNA encoding Myc and Cyclin T1 induces cardiac regeneration and improves cardiac function after myocardial injury.’ Preprint (2023).

DOI: https://doi.org/10.1101/2023.08.02.551469

From the labs of Catherine H. Wilson, University of Cambridge and James E. Hudson, QIMR Berghofer Medical Research Institute

Used:
FGF-2 (Qk002)
Activin A (Qk001)

Farhan, F. et al. ‘Extracellular matrices modulate differentiation of human embryonic stem cell-derived hepatocyte-like cells with spatial hepatic features.’ Research Square (2023).

DOI: https://doi.org/10.21203/rs.3.rs-3157108/v1

From the lab of Wei Cui, Imperial College London

Used:
Activin A (Qk001)

Mulas, C. et al. ‘ERK signalling orchestrates metachronous transition from naïve to formative pluripotency.’ Preprint (2023).

DOI: https://doi.org/10.1101/2023.07.20.549835

From the labs of Austin Smith, University of Cambridge and Kevin J. Chalut, University of Exeter

Used:
hLIF (Qk036)

Chen, H.-J. C. et al. ‘Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss.’ Preprint (2023).

DOI: https://doi.org/10.1101/2023.07.18.549357

From the labs of John C. Marioni, European Bioinformatics Institute and Florian T. Merkle, University of Cambridge

Used:
BDNF (Qk050)

Dinarello, A. et al. ‘STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia.’ Cell Death Discov. 9, 1–12 (2023).

DOI: https://doi.org/10.1038/s41420-023-01507-w

From the lab of Graziano Martello and Francesco Argenton, University of Padova

Used:
hLIF (Qk036)

Ferlazzo, G. M. et al. ‘Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.’ Nat Commun 14, 3962 (2023).

DOI: https://doi.org/10.1038/s41467-023-39552-9

From the lab of Graziano Martello, University of Padova

Used:
hLIF (Qk036)
FGF-2 (Qk002)

Weatherbee, B. A. T. et al. ‘Pluripotent stem cell-derived model of the post-implantation human embryo.’ Nature 1–10 (2023).

DOI: https://doi.org/10.1038/s41586-023-06368-y

From the lab of Magdalena Zernicka-Goetz, University of Cambridge

Used:
Activin A (Qk001)

Weatherbee, B. A. et al. ‘Transgene directed induction of a stem cell-derived human embryo model.’ Nature (2023).

DOI: https://doi.org/10.1038/s41586-023-06368-y

From the lab of Magdalena Zernicka-Goetz, University of Cambridge

Used:
Activin A (Qk001)

Lyra-Leite, D. M. et al. ‘Nutritional requirements of human induced pluripotent stem cells.’ Stem Cell Reports 18, 1371–1387 (2023).

DOI: 10.1016/j.stemcr.2023.05.004

From the lab of Paul W. Burridge, Northwestern University Feinberg School of Medicine

Used:
TGFβ3 (Qk054)

Choi, W et al. ‘Establishment of Patient-Derived Organoids Using Ascitic or Pleural Fluid from Cancer Patients’. Cancer Res Treat (2023).

DOI: 10.4143/crt.2022.1630

From the lab of Sun-Young Kong, National Cancer Center, Korea

Used:
R-spondin-1 (Qk006)

Agarwal, D. & Wahlin, K. ‘Differentiation of RGC Induced Neurons (RGC-iNs).’ (2023).

https://www.protocols.io/view/differentiation-of-rgc-induced-neurons-rgc-ins-cu5jwy4n.html

From the lab of Karl Wahlin, University of California San Diego

Used:
BDNF (Qk050)
GDNF (Qk051)

Hennessy, M. J., Fulton, T., Turner, D. A. & Steventon, B. ‘Negative feedback on Retinoic Acid by Brachyury guides gastruloid symmetry-breaking.’ (2023).

DOI: https://doi.org/10.1101/2023.06.02.543388

From the labs of David A. Turner, University of Liverpool and Ben Steventon, University of Cambridge

Used:
Murine LIF (Qk018)

Agarwal, R. et al. ‘Human epidermis organotypic cultures, a reproducible system recapitulating the epidermis in vitro.’ Experimental Dermatology 32, 1143–1155 (2023).

DOI: https://doi.org/10.1111/exd.14823

From the labs of Emmanuel Contassot and Alexander A. Navarini, University of Basel

Used:
Noggin (Qk034)
R-spondin 1 (Qk006)
FGF10 (Qk003)

Blackford, S. J. I. et al. ‘RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling.’ Biomaterials 293, 121982 (2023).

DOI: https://doi.org/10.1016/j.biomaterials.2022.121982

From the labs of Tamir Rashid, Imperial College London and Eileen Gentleman, King’s College London.

Used:
Activin A (Qk001)

Fejzo, M. et al. ‘Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy.’ Preprint (2023).

DOI: https://doi.org/10.1101/2023.06.02.542661

From the lab of Stephen O’Rahilly, University of Cambridge, UK and Nicholas Mancuso, University of Southern California, USA.

Used:
Human GDF-15 protein (Qk017)

Carbognin, E. et al. ‘Esrrb guides naive pluripotent cells through the formative transcriptional programme.’ Nat Cell Biol 25, 643–657 (2023).

DOI: https://doi.org/10.1038/s41556-023-01131-x

From the labs of Jamie A. Hackett, European Molecular Biology Laboratory EMBL-Rome, Davide Cacchiarelli, Telethon Institute of Genetics and Medicine and Graziano Martello, University of Padua.

Used:
Zebrafish FGF-2 protein (Qk002)
Activin A protein (Qk001)
Human LIF protein (Qk036)

Williams, T. L. et al. ‘Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands.’ Frontiers in Endocrinology 14, (2023).

DOI: https://doi.org/10.3389/fendo.2023.1139121

From the lab of Anthony Davenport, University of Cambridge

Used:
Zebrafish FGF-2 protein (Qk002)

Heidari Khoei, H., Javali, A., Kagawa, H. et al. ‘Generating human blastoids modeling blastocyst-stage embryos and implantation.’ Nat Protoc, (2023)

DOI: https://doi.org/10.1038/s41596-023-00802-1

From the lab of Nicolas Rivron, IMBA, Austrian Academy of Sciences

Used:
Human LIF protein (Qk036)

2022

Karusheva, Y. et al. ‘The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels’. The Journal of Applied Laboratory Medicine, (2022)

DOI: https://doi.org/10.1093/jalm/jfac055

From the lab of Stephen O’Rahilly, University of Cambridge

Used:
TGF-β growth factors, including GDF-15 (Qk017)

Barsby, T. et al. ‘Differentiating functional human islet-like aggregates from pluripotent stem cells’. STAR Protocols, 03:04 (2022)

DOI: https://doi.org/10.1016/j.xpro.2022.101711

From the lab of Timo Otonkoski, University of Helsinki

Used:
Activin A (Qk001)

Beucher, A. et al. ‘The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A’. Nat Cell Biol, 24, 1528–1540 (2022)

DOI: https://doi.org/10.1038/s41556-022-00996-8

From the lab of Jorge Ferrer, Centre for Genomic Regulation (CRG)

Used:
Activin A (Qk001)

Bao, M. et al. ‘Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension’. Nat Cell Biol, 24, 1341–1349 (2022)

DOI: https://doi.org/10.1038/s41556-022-00984-y

From the lab of Magdalena Zernicka-Goetz, University of Cambridge

Used:
Activin A (Qk001)

Jobbins, A. et al. ‘Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease’. Nucleic Acids Research, 50:06 (2022)

DOI: https://doi.org/10.1093/nar/gkac165

From the lab of Santiago Vernia, LMS London Institute of Medical Sciences

Used:
Activin A (Qk001)

Vankatesan, M. et al. ‘Recombinant production of growth factors for application in cell culture’. iScience, 25:10 (2022)

DOI: https://doi.org/10.1016/j.isci.2022.105054

From the lab of Alexi Savchenko, University of Toronto

Used:
TGF-β1 (Qk010)

Tan, J. et al. ‘Oxygen is a critical regulator of cellular metabolism and function in cell culture’. bioRxiv, (2022)

DOI: https://doi.org/10.1101/2022.11.29.516437

From the lab of Daniel J. Fazakerley, University of Cambridge

Used:
FGF-2 (Qk002)

Ragusa, D. et al. ‘Dissecting infant leukaemia developmental origins with a hemogenic gastruloid model’. bioRxiv, (2022)

DOI: https://doi.org/10.1101/2022.10.07.511362

From the lab of Cristina Pina, Brunel University

Used:
Activin A (Qk001)

Miguel-Escalada, I. et al. ‘Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster’. Developmental Cell, 57:16, (2022)

DOI: https://doi.org/10.1016/j.devcel.2022.07.014

From the lab of Jorge Ferrer, Centre for Genomic Regulation (CRG)

Used:
Activin A (Qk001)

Bergmann, S. et al. ‘Spatial profiling of early primate gastrulation in utero’. Nature, 609, 136–143, (2022)

DOI: https://doi.org/10.1038/s41586-022-04953-1

From the lab of Thorsten E. Boroviak, University of Cambridge

Used:
Noggin (Qk034)

Meek, S. et al. ‘Stem Cell-Derived Porcine Macrophages as a New Platform for Studying Host-Pathogen Interactions’. BMC Biology, 20:14 (2022)

DOI: doi.org/10.1186/s12915-021-01217-8.

From the lab of Tom Burdon, University of Edinburgh

Used:
Activin A (Qk001)
FGF-2 / bFGF 154 aa (Qk027)

Drozd, A. et al. ‘Progesterone Receptor Modulates Extraembryonic Mesoderm and Cardiac Progenitor Specification during Mouse Gastrulation’. Int. J. Mol. Sci, (2022)

DOI: https://doi.org/10.3390/ijms231810307

From the lab of Elisabetta Ferretti, University of Copenhagen

Used:
Activin A (Qk001)
BMP-4 (Qk038)
bFGF (Qk027)

Barber, L. et al. ‘Selectivity and stability of N-terminal targeting protein modification chemistries’. Royal Society of Chemistry, (2022)

DOI: https://doi.org/10.1039/D2CB00203E

From the lab of Dr Christopher D. Spicer, University of York

Dinarello, A. et al. ‘STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia’. bioRxiv (2022)

DOI: doi.org/10.1186/s12915-021-01217-8.

From the lab of Francesco Argenton, University of Padova, Italy.

Used:
Human LIF protein (Qk036)

Tomaz, R. et al. ‘Generation of functional hepatocytes by forward programming with nuclear receptors’. eLife, 11:e71591 (2022)

DOI: doi.org/10.7554/eLife.71591

From the lab of Ludovic Vallier, University of Cambridge

Used:
FGF-2 / bFGF 154 aa (Qk027)

2021

Luo, L, et al. ‘Hydrostatic Pressure Promotes Chondrogenic Differentiation and Microvesicle Release from Human Embryonic and Bone Marrow Stem Cells’. Biotechnology Journal (2021)

DOI: 10.1002/biot.202100401.

From the lab of Alicia El Haj, University of Birmingham

Used:
Activin A (Qk001)
FGF-2 / bFGF 145 aa (Qk025)
BMP-2 (Qk007)

Huang, T et al. ‘Sex-Specific Chromatin Remodelling Safeguards Transcription in Germ Cells’. Nature, 600, 737–742 (2021)

DOI: doi.org/10.1038/s41586-021-04208-5.

From the lab of Petra Hajkova, MRC London Institute of Medical Sciences

Used:
BMP-2 (Qk007)

Cimino, I. et al. ‘Activation of the hypothalamic–pituitary–adrenal axis by exogenous and endogenous GDF15’. PNAS, 118, 27 (2021).

DOI: doi: doi.org/10.1073/pnas.2106868118

From the lab of Stephen O’Rahilly, University of Cambridge

Used:
GDF-15 (Qk017)

Williams, T. L. et al. ‘Human Embryonic Stem Cell-Derived Cardiomyocyte Platform Screens Inhibitors of SARS-CoV-2 Infection’. Communications Biology 4, 926 (2021).

DOI: doi: 10.1038/s42003-021-02453-y.

From the lab of Anthony Davenport, University of Cambridge

Used:
zFGF-2 / bFGF (Qk002)

Kinoshita, M. et al. Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency. Cell Stem Cell (2020)

DOI: doi:10.1016/j.stem.2020.11.005.

From the lab of Austin Smith, University of Cambridge & University of Exeter

Used:
Activin A PLUS (Qk005)
zFGF-2 / bFGF (Qk002)

Andreasson, L., Evenbratt, H., Mobini, R. & Simonsson, S. Differentiation of induced pluripotent stem cells into definitive endoderm on Activin A-functionalized gradient surfaces. J Biotechnol 325, 173–178 (2021).

DOI: doi.org/10.1186/s12915-021-01217-8.

From the lab of Stina Simonsson, University of Gothenburg

Used:
Activin A (Qk001)

2020

Borkowska, M. & Leitch, H. G. Mouse Primordial Germ Cells: In Vitro Culture and Conversion to Pluripotent Stem Cell Lines. Methods Mol Biol 2214, 59–73 (2021).

DOI: 10.1007/978-1-0716-0958-3_5

From the lab of Harry Leitch, Imperial College London

Used:
mouse LIF (Qk018)

Zorzan, I. et al. The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs. Nat Commun 11, 2364 (2020).

DOI: 10.1038/s41467-020-16205-9

From the lab of Graziano Martello, University of Padua

Used:
Activin A (Qk001)
zFGF-2 / bFGF  (Qk002)

Wamaitha, S. E. et al. IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche. Nat Commun 11, 764 (2020).

DOI: 10.1038/s41467-020-14629-x

From the lab of Harry Leitch, Imperial College London

Used:
Activin A (Qk001)

2019

Stuart, H. T. et al. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell 25, 388-406.e8 (2019).

DOI: 10.1016/j.stem.2019.07.009

Reviewers comments available to view: Stadtfeld, M. Evaluation of Stuart et al.: Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell 25, 297–298 (2019). doi: 10.1016/j.stem.2019.08.009

From the lab of José Silva, University of Cambridge

Used:
Activin A (Qk001)
zFGF2 / bFGF (Qk002)
mouse LIF (Qk018)

2018

Blackford, S. J. I. et al. Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell-Derived Hepatocytes for Cell-Based Therapy. Stem Cells Transl Med 8, 124–137 (2019).

DOI: 10.1002/sctm.18-0084

From the lab of Tamir Rashid, Kings College London

Used:
Activin A (Qk001)