Transforming growth factor beta (TGF-β) superfamily

Transforming growth factor beta superfamily encompasses a range of proteins including TGF-beta, Growth Differentiation Factors (GDFs), Bone Morphogenetic Proteins (BMPs), Glial-derived Neurotrophic Factors (GDNFs), Inhibins, Activins, Nodal, Lefty, and Mülllerian Inhibiting Substance (MIS).

Shared among these members are dimeric structures and receptor complexes composed of both type I and type II receptor subunits, each containing serine/threonine kinase domains. Upon ligand binding, the type II receptor phosphorylates and activates the type I receptor, initiating a signaling cascade reliant on Smad proteins that ultimately regulates gene expression.

This superfamily of proteins plays diverse roles in  embryonic development, morphogenesis, adult stem cell differentiation, wound healing, immune regulation, cancer and inflammation.

Qkine robust animal-free manufacturing platform, along with rigorous quality control procedures, ensure that all our r-spondin proteins are:

  • animal-free (AOF) and carrier protein-free
  • highly pure (>98%, by SDS-PAGE quantitative densitometry)
  • highly bioactive (equally or more bioactive than other dominant suppliers) and come with our Bioactivity Guarantee
  • highly reproducible with excellent lot-to-lot consistency

Qkine is committed to manufacturing bioactive proteins of the highest quality to enhance scientific outcomes and improve reproducibility. All our products rigorously adhere to the Nine-point Qkine Quality Commitment.

Any questions? Contact us, our dedicated team of stem cell specialists is available to answer any queries you may have and to give expert support.

    ProteinDescriptionPrice Product informationhf:categories
    Qk005 Activin A PLUS (human) Qkine protein vial
    Recombinant human/mouse/rat Activin A PLUS ™ protein (Qk005)$210.00$3,100.00Show detailsgrowth-factor-cytokine activin-proteins hepatocyte ipsc-esc-maintenance optimised-by-qkine pluripotent-stem-cells-ipsc-esc tgf-beta-family growth-factor-cytokine-by-research-area growth-factor-cytokine-by-cell-type
    Qk007 BMP2 (human) Qkine protein vial
    Recombinant human/mouse/rat/bovine/porcine BMP-2 protein (Qk007)$280.00$3,950.00Show detailsgrowth-factor-cytokine bmp-family bovine human mouse pluripotent-stem-cells-ipsc-esc porcine rat tgf-beta-family growth-factor-cytokine-by-species growth-factor-cytokine-by-cell-type
    Qk038-BMP4-human-qkine-vial
    Recombinant human BMP-4 protein (Qk038)$280.00$3,950.00Show detailsgrowth-factor-cytokine bmp-family epithelial hepatocyte human ipsc-esc-maintenance mesenchymal neural organoid pluripotent-stem-cells-ipsc-esc tgf-beta-family growth-factor-cytokine-by-cell-type growth-factor-cytokine-by-research-area growth-factor-cytokine-by-species
    Qkine recombinant GDF-5 protein vial
    Recombinant human GDF-5 protein (Qk070)$280.00$3,950.00Show detailsgrowth-factor-cytokine bmp-family human mesenchymal tgf-beta-family growth-factor-cytokine-by-species growth-factor-cytokine-by-cell-type
    Qkine recombinant porcine TGF beta 3 protein vial
    Recombinant porcine TGF-β3 protein (Qk084)$355.00$4,950.00Show detailscellular-agriculture pluripotent-stem-cells-ipsc-esc porcine tgf-beta-family growth-factor-cytokine-by-research-area growth-factor-cytokine-by-cell-type growth-factor-cytokine-by-species growth-factor-cytokine
    Qkine TGF-β2 recombinant protein vial
    Recombinant human/bovine/porcine TGF-β2 protein (Qk072)$355.00$4,950.00Show detailsgrowth-factor-cytokine bovine hematopoietic human immune ipsc-esc-maintenance ipscs-differentiation pluripotent-stem-cells-ipsc-esc porcine tgf-beta-family growth-factor-cytokine-by-species growth-factor-cytokine-by-cell-type growth-factor-cytokine-by-research-area
    Qk034-Noggin-human-qkine-vial
    Recombinant human noggin protein (Qk034)$280.00$3,950.00Show detailsgrowth-factor-cytokine bmp-family human ipsc-esc-maintenance mouse-es-cell neural organoid pluripotent-stem-cells-ipsc-esc tgf-beta-family growth-factor-cytokine-by-species growth-factor-cytokine-by-research-area growth-factor-cytokine-by-cell-type
    Qk033 Noggin (mouse) Qkine protein vial
    Recombinant mouse/rat noggin protein (Qk033)$280.00$3,950.00Show detailsgrowth-factor-cytokine bmp-family epithelial ipsc-esc-maintenance mouse mouse-es-cell neural organoid pluripotent-stem-cells-ipsc-esc rat tgf-beta-family growth-factor-cytokine-by-cell-type growth-factor-cytokine-by-research-area growth-factor-cytokine-by-species
    Qk018 TGF beta 1 PLUS (human) Qkine protein vial
    Recombinant human/bovine/porcine TGF-β1 PLUS ™ protein (Qk010)$355.00$4,950.00Show detailsbovine human ipsc-esc-maintenance optimised-by-qkine pluripotent-stem-cells-ipsc-esc porcine tgf-beta-family growth-factor-cytokine-by-species growth-factor-cytokine-by-research-area growth-factor-cytokine-by-cell-type growth-factor-cytokine
    Recombinant human TGF-β3 protein (Qk054)
    Recombinant human TGF-β3 protein (Qk054)$355.00$4,950.00Show detailshuman ipsc-esc-maintenance tgf-beta-family growth-factor-cytokine-by-species growth-factor-cytokine-by-research-area growth-factor-cytokine

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