- Recombinant porcine HGF protein is a potent, high-purity NK1 isoform of porcine hepatocyte growth factor (HGF). Porcine recombinant protein HGF differs from human HGF at several key amino acid residues that are predicted to affect bioactivity and receptor binding. Use of species-specific HGF growth factor will facilitate media optimization for cellular agriculture (cultivated meat) and veterinary applications. Also available is Qk060-FG Bovine HGF (NK1). The highly scalable animal origin-free manufacture and enhanced bioactivity make this suitable for chemically-defined media and reproducible scale-up.20kDa naturally occurring isoform of HGF, animal origin-free and carrier-protein free.
- Recombinant bovine HGF (NK1) protein is a potent, high-purity NK1 isoform of bovine hepatocyte growth factor (HGF). Bovine HGF differs from human HGF at several key amino acid residues that are predicted to affect bioactivity and receptor binding. Use of species-specific HGF growth factor will facilitate media optimization for cellular agriculture (cultivated meat) and veterinary applications. Also available is Qk061-FG Porcine HGF (NK1). The highly scalable animal-free manufacture and enhanced bioactivity make this suitable for chemically-defined media and reproducible scale-up.20kDa naturally occurring isoform of HGF, animal origin-free and carrier-protein free.
- Recombinant bovine/porcine FGF2 protein 154 aa (bFGF/basic FGF), this is the long form of FGF-2 used for the development of optimized serum-free culture media for species-specific bovine (cow) and porcine (pig) cultivated meat and veterinary research applications. Used in comparative media optimization studies with Qk040 porcine/bovine FGF-2 145 aa.High quality food grade 16 kDa FGF-2 / bFGF 154 aa protein, animal origin-free (AOF) and carrier-protein free (CF).
- Recombinant bovine/porcine FGF-2 protein 145aa (bFGF/basic FGF) for the development of species-specific bovine (cow) and porcine (pig) cellular agriculture protocols and veterinary research applications. Can be used in comparative cell culture media optimization studies alongside Qk056, the 154aa form of porcine/bovine FGF-2.Qkine high qualify food recombinant bovine/porcine FGF-2 protein 145aa protein is a high purity 16 kDa protein, animal origin-free (AOF) and carrier-protein free (CF).
- Porcine EGF is an essential growth factor belonging to the Epidermal Growth Factor family that stimulates the proliferation and differentiation of cells. It is used for the differentiation of induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) towards epithelial, neural, mesoderm and hematopoietic lineages.Qkine high quality food grade porcine EGF is becoming rapidly adopted as a species-specific growth factor in the cultivated meat sector. Porcine EGF is also an essential component of many organoid media supporting the culture and differentiation of a wide variety of organoids including intestine and liver organoids.Porcine EGF has a molecular weight of 6.3 kDa. This protein is animal origin-free, carrier protein-free, His-tag-free and non-glycosylated to ensure a pure recombinant protein with exceptional lot-to-lot consistency.
- Zebrafish fibroblast growth factor 2 (FGF-2/bFGF/basic FGF) can be used to support the maintenance and proliferation of induced pluripotent (iPSC) and embryonic stem cells (ESC).Qkine zebrafish FGF-2 is a high quality food grade 17 kDa protein, animal origin-free (AOF) and carrier-protein free (CF).
- Transforming Growth Factor beta 2 (TGF-β2), part of the TGF-β superfamily, regulates a wide array of cellular processes, including proliferation, differentiation, wound healing, apoptosis, metabolism, embryogenesis, and tissue repair. It is an essential growth factor in many embryonic and induced pluripotent stem cell culture media.Qkine TGF-β2 (Qk112-FG) is a high quality food grade protein with a molecular weight of 25.4 kDa. This protein is carrier-free and tag-free to ensure its purity with exceptional lot-to-lot consistency. TGF-β2 is suitable for the culture of reproducible and high-quality stem cells and other relevant cells.
- Follistatin-resistant activin A (FRACTA) protein has been engineered to prevent binding to the natural inhibitor, follistatin. Activin A activity is regulated in vivo by follistatin, a high-affinity inhibitor; follistatin accumulates in stem cell culture, where it inhibits activin A.High qualifty food grade recombinant follistatin-resistant activin A protein (FRACTA) has equivalent bioactivity to wild-type activin A (Qk001) but does not bind follistatin so is resistant to feedback inhibition. High purity 26 kDa dimer comprising engineered mature domain of activin A protein, animal origin-free (AOF) and carrier-protein free (CF). This specialised activin A has been developed in Marko Hyvönen’s group in the University of Cambridge.
- Bovine/porcine high quality food grade recombinant activin A PLUS™ protein is an optimised biologically active truncation of the mature domain of human activin A protein. The EC50 and activity in stem cell culture of activin A PLUS™ is equivalent to the full mature domain activin A.High purity 24 kDa dimer comprising truncated mature domain of activin A protein, animal origin-free (AOF) and carrier-protein free (CF). Recombinant activin A PLUS™ is designed to be manufactured at scale for cost-effective, large-scale stem cell culture applications for cultured meat and fat.
- Activin A is a TGF-β family growth factor regulating embryonic development, cell proliferation, differentiation, and immune responses. Food grade activin A is frequently used to maintain pluripotency in induced pluripotent and embryonic stem cell cultures for cultivated meat and fat. High quality food grade recombinant bovine/porcine activin A protein is a high-purity mature bioactive dimer of 26 kDa. It is animal origin-free, carrier protein-free, and tag-free to ensure its purity with exceptional lot-to-lot consistency.
- Interleukin-7 (IL-7) is a vital cytokine essential for immune system regulation, particularly in the development and maintenance of T cells, playing a crucial role in both adaptive and innate immune responses. Recombinant human IL-7 stimulates the development of lymphoid progenitor cells.Qkine has optimised the IL-7 manufacture process to produce a highly bioactive protein with excellent lot-to-lot consistency for enhanced experimental reproducibility.IL-7 is a highly pure 17.5 kDa monomer, animal origin-free (AOF) and carrier-protein-free (CF).
- Human recombinant activin E PLUS protein is an optimised biologically active truncation of the mature domain of human activin E protein. Activin E is a member of the transforming growth factor-beta (TGF-ß) superfamily, a group of proteins that play key roles in regulating cell growth, differentiation, and inflammation. The tag-free form of activin E PLUS is of significant interest for drug discovery across various fields. An Avi-tag version, recombinant human activin E PLUS Avi-tag protein (Qk082), is also available upon request. Human activin E PLUS protein is the first entirely animal origin-free recombinant human activin E protein for highly reproducible results and compatible with chemically-defined stem cell media.High purity 23.2 kDa dimer comprising truncated mature domain, animal origin-free (AOF) and carrier-protein free (CF).
- Fibroblast Growth Factor 18 (FGF-18), a member of the FGF family, characterized by its heparin-binding properties plays a significant role in regulating diverse biological processes such as embryonic development, skeletal and bone development, cartilage maintenance, angiogenesis and tissue repair.In cell culture, FGF-18 is widely used to support cell culture maintenance and proliferation, promote chondrogenic and osteogenic differentiation of stem cells, stimulate angiogenesis, and enhance tissue regeneration.FGF-18 is a high purity truncated protein with a molecular weight of 20.2 kDa. This protein is carrier-free and tag-free to ensure its purity with exceptional lot-to-lot consistency. Qkine Fibroblast Growth Factor 18 is suitable for the culture of reproducible and high-quality stem cells, primary cells and other relevant cells.
- Epidermal growth factor (EGF), a member of the EGF family of proteins, plays a significant role in regulating cellular processes such as cell growth, proliferation, differentiation, development, and tissue homeostasis. It is an essential growth factor in many stem cells and organoid culture media.In cell culture, mouse EGF is crucial for stem cell maintenance, proliferation, differentiation, organoid culture growth and survival. It is also widely used for disease modelling, drug screening, tissue engineering, and regenerative medicine. Overall, EGF is a key player in cellular regulation and functions.Mouse EGF is a high purity protein with a molecular weight of 6.1 kDa, animal origin-free, carrier-free and tag-free to ensure its purity with exceptional lot-to-lot consistency. Qkine mouse EGF is suitable for the culture of reproducible and high-quality stem cells and various tissue-specific organoids.
- Tumor necrosis factor-alpha (TNF-α) is a cytokine involved in cell signaling, primarily produced by immune cells like macrophages. It plays a central role in inflammation, immunity, and regulating cell survival and death.Human TNF-α has a molecular weight of 17.3 kDa, animal origin-free, carrier-free and protein tag-free to ensure its purity with exceptional lot-to-lot consistency. Qk083 TNF-alpha is suitable for the culture of reproducible and high-quality hematopoietic stem cells and other relevant cells.
- Interleukin-6 (IL-6) is a multifunctional cytokine that regulates immune responses and inflammation. It is produced by various cells, including immune cells such as T cells and macrophages, as well as non-immune cells like fibroblasts and endothelial cells. Human IL-6 has a molecular weight of 20.9 kDa. This protein is animal origin-free, carrier-free and tag-free to ensure its purity with exceptional lot-to-lot consistency. IL-6 is suitable for the culture of reproducible and high-quality hematopoietic stem cells and other relevant cells.
- Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine that is secreted primarily by mast cells, T-cells, eosinophils, and basophils. IL-4 plays a crucial role in hematopoiesis, the regulation of antibody production, the stimulation of activated B cell and T cell proliferation, and the differentiation of B cells into plasma cellsHuman IL-4 has a molecular weight of 15.1 kDa. This protein is animal origin-free, carrier-free and tag-free to ensure its purity with exceptional lot-to-lot consistency. Qk092 is suitable for the culture of reproducible and high-quality stem cells and other relevant cells.
- Transforming Growth Factor beta 2 (TGF-β2), part of the TGF-β superfamily, regulates a wide array of cellular processes, including proliferation, differentiation, wound healing, apoptosis, metabolism, embryogenesis, and tissue repair. It is an essential growth factor in many embryonic and induced pluripotent stem cell culture media.TGF-beta 2 is a high purity protein with a molecular weight of 25.4 kDa. This protein is carrier-free and tag-free to ensure its purity with exceptional lot-to-lot consistency. Qkine TGF-beta 2 is suitable for the culture of reproducible and high-quality stem cells and other relevant cells.
- Dickkopf-related protein 1 (DKK-1) is a key player in the Wnt signaling pathway and regulates embryonic development, tissue balance, and diseases, including cancer. DKK-1 is a member of the DKK protein family and acts as a potent Wnt pathway antagonist.In cell culture, DKK-1 is pivotal for controlling cell fate, self-renewal, and differentiation by inhibiting the canonical Wnt/β-catenin pathway through LRP5/6 co-receptors. DKK-1 has been widely used in various applications including guiding stem cell differentiation, particularly in neural and osteogenic pathways, and mimicking dysregulated Wnt signaling seen in cancers. Its inhibitory role is also crucial for anterior development.Human DKK-1 has a molecular weight of 25.7 kDa, animal origin-free, carrier-free and tag-free to ensure its purity with exceptional lot-to-lot consistency. DKK-1 is suitable for the culture of reproducible and high-quality stem cells and other relevant cells.
- Fibroblast Growth Factor 1 (FGF-1) can stimulate growth and differentiation of endothelial and epithelial cells and the development of organoids. FGF-1 can also be used for the maintenance of oligodendrocytes and astroglia as well as bone marrow-derived mesenchymal and hematopoietic stem cells.Qkine human FGF-1 has a molecular weight of 15.9 kDa. This protein is animal origin-free, carrier-free and tag-free to ensure its purity with exceptional lot-to-lot consistency. Qk071 is suitable for the culture of reproducible mesenchymal, endothelial, haematopoietic, glial, and other relevant cells.
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