Dickkopf (DKK) family

Qkine Dickkopf (DKK) family includes recombinant human Dickkopf-related protein 1, which is a key player in the Wnt signaling pathway and regulates embryonic development, tissue balance, and diseases, including cancer.

Qkine has developed a fully animal-origin free (AOF) DKK-1 to support translational and sensitive studies. Using high-purity AOF proteins improves reproducibility by eliminating contamination or off-target effects from trace animal components and co-purifying related proteins naturally secreted by mammalian protein expression systems.

As we do for all our products, we compared Qkine AOF Dickkopf-related protein 1 bioactivity with mammalian-expressed DKK-1 from main suppliers. The comparative bioactivity data demonstrate that Qkine DKK-1 (Qk068) has equivalent bioactivity to the mammalian-expressed DKK-1 from an alternative major supplier. Qkine thus provides the first reliable source of high-quality animal-free DKK-1 for highly-defined reproducible culture of stem cells, neuronal cells, osteoblasts and other applications.

Qkine robust animal-free manufacturing platform, along with rigorous quality control procedures, ensure that all our Dickkopf proteins are:

• animal origin-free (AOF) and carrier protein-free
• highly pure (>98%, by SDS-PAGE quantitative densitometry)
• highly bioactive (equally or more bioactive than other dominant suppliers) and come with our Bioactivity Guarantee
• highly reproducible with excellent lot-to-lot consistency

Qkine is committed to manufacturing bioactive proteins of the highest quality to enhance scientific outcomes and improve reproducibility. All our products rigorously adhere to the Nine-point Qkine Quality Commitment.

Please contact us if you have any questions, our dedicated team of stem cell specialists is available to answer any queries you may have.