Transforming growth factor beta (TGF-β) superfamily

Members of the TGF-beta superfamily, such as activins, TGF-beta 1, TGF-beta 2, TGF-beta 3, GDF-5, GDF-15, GDNF, and BMPs, play crucial roles in governing various developmental and physiological processes. These proteins contribute to the regulation of fundamental cellular properties and vital cellular processes, such as cell growth, differentiation, proliferation, survival, apoptosis, morphogenesis, and tissue remodeling.

Transforming growth factor beta superfamily encompasses a range of proteins including TGF-beta, Growth Differentiation Factors (GDFs), Bone Morphogenetic Proteins (BMPs), Glial-derived Neurotrophic Factors (GDNFs), Inhibins, activins, nodal, lefty, and Mülllerian Inhibiting Substance (MIS).

Shared among these members are dimeric structures and receptor complexes composed of both type I and type II receptor subunits, each containing serine/threonine kinase domains. Upon ligand binding, the type II receptor phosphorylates and activates the type I receptor, initiating a signaling cascade reliant on Smad proteins that ultimately regulates gene expression.

This superfamily of proteins plays diverse roles in  embryonic development, morphogenesis, adult stem cell differentiation, wound healing, immune regulation, cancer and inflammation.

Qkine robust animal-free manufacturing platform, along with rigorous quality control procedures, ensure that all our transforming growth factor beta proteins are:

  • animal origin-free (AOF) and carrier protein-free
  • highly pure (>98%, by SDS-PAGE quantitative densitometry)
  • highly bioactive (equally or more bioactive than other dominant suppliers) and come with our Bioactivity Guarantee
  • highly reproducible with excellent lot-to-lot consistency

Qkine is committed to manufacturing bioactive proteins of the highest quality to enhance scientific outcomes and improve reproducibility. All our products rigorously adhere to the Nine-point Qkine Quality Commitment.

Any questions? Contact us, our dedicated team of stem cell specialists is available to answer any queries you may have and to give expert support.

TGF beta superfamily

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