Recombinant human Shh protein (Qk055)
Sonic hedgehog (Shh) protein has many applications in the neural stem cell field. Shh is used as a growth factor (cytokine) to induce cell types in ventral domains at various levels in the forebrain, midbrain, hindbrain, and spinal cord. It plays a significant role in patterning human-induced pluripotent stem cells (iPSC) towards ventral forebrain fate in the forebrain region, dopaminergic neuronal fate in the midbrain region, and serotonergic neuronal fate in the hindbrain region. Shh signaling is crucial in deriving motor neurons from iPSCs to model neuromuscular disorders.
SHH C24II is the bioactive N-terminal region, encompassing Cys24-Gly197 (Cys24Ile-Ile), animal-origin free (AOF) and carrier protein-free.
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