Transforming growth factor beta (TGF-β) superfamily

Members of the TGF-beta superfamily, such as activins, TGF-beta 1, TGF-beta 2, TGF-beta 3, GDF-5, GDF-15, GDNF, and BMPs, play crucial roles in governing various developmental and physiological processes. These proteins contribute to the regulation of fundamental cellular properties and vital cellular processes, such as cell growth, differentiation, proliferation, survival, apoptosis, morphogenesis, and tissue remodeling.

Transforming growth factor beta superfamily encompasses a range of proteins including TGF-beta, Growth Differentiation Factors (GDFs), Bone Morphogenetic Proteins (BMPs), Glial-derived Neurotrophic Factors (GDNFs), Inhibins, activins, nodal, lefty, and Mülllerian Inhibiting Substance (MIS).

Shared among these members are dimeric structures and receptor complexes composed of both type I and type II receptor subunits, each containing serine/threonine kinase domains. Upon ligand binding, the type II receptor phosphorylates and activates the type I receptor, initiating a signaling cascade reliant on Smad proteins that ultimately regulates gene expression.

This superfamily of proteins plays diverse roles in  embryonic development, morphogenesis, adult stem cell differentiation, wound healing, immune regulation, cancer and inflammation.

Qkine robust animal-free manufacturing platform, along with rigorous quality control procedures, ensure that all our transforming growth factor beta proteins are:

  • animal origin-free (AOF) and carrier protein-free
  • highly pure (>98%, by SDS-PAGE quantitative densitometry)
  • highly bioactive (equally or more bioactive than other dominant suppliers) and come with our Bioactivity Guarantee
  • highly reproducible with excellent lot-to-lot consistency

Qkine is committed to manufacturing bioactive proteins of the highest quality to enhance scientific outcomes and improve reproducibility. All our products rigorously adhere to the Nine-point Qkine Quality Commitment.

Any questions? Contact us, our dedicated team of stem cell specialists is available to answer any queries you may have and to give expert support.

TGF beta superfamily

Showing 1–12 of 15 results

    Vial image activin A

    Recombinant human activin A protein (Qk001)

    High purity and bioactivity animal origin-free recombinant activin A for highly reproducible stem cell culture.

    £205.00 – £2,900.00
    View product This product has multiple variants. The options may be chosen on the product page

    Vial image activin A PLUS

    Recombinant human activin A PLUSâ„¢ protein (Qk005)

    Optimized biologically active truncation of the mature domain of human activin A protein for cost-effective, large-scale stem cell culture applications.

    £155.00 – £2,300.00
    View product This product has multiple variants. The options may be chosen on the product page

    Recombinant human follistatin-resistant activin A (FRACTA) protein (Qk035)

    Recombinant human follistatin-resistant activin A (FRACTA) protein (Qk035)

    Equivalent bioactivity to wild-type activin A, engineered to prevent binding to the natural activin A inhibitor follistatin, preventing feedback inhibition in cell cultures.

    £205.00 – £2,900.00
    View product This product has multiple variants. The options may be chosen on the product page

    Vial image

    Recombinant human activin E PLUSâ„¢ protein (Qk067)

    Optimized biologically active truncation of the mature domain of human activin E protein, animal origin-free.

    £255.00 – £3,600.00
    View product This product has multiple variants. The options may be chosen on the product page

    Vial image BMP-2

    Recombinant human BMP-2 protein (Qk007)

    Animal origin-free BMP-2 key regulator of embryogenesis and potent differentiation factor of embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) towards endoderm fates.

    £205.00 – £2,900.00
    View product This product has multiple variants. The options may be chosen on the product page

    Qk038 BMP-4 vial image

    Recombinant human BMP-4 protein (Qk038)

    Highly pure animal origin-free protein, key regulator of embryogenesis and supports the differentiation of embryonic stem cells and induced pluripotent stem cells.

    £205.00 – £2,900.00
    View product This product has multiple variants. The options may be chosen on the product page

    Qk070 GDF-5 vial image

    Recombinant human GDF-5 protein (Qk070)

    £205.00 – £2,900.00
    View product This product has multiple variants. The options may be chosen on the product page

    Qk017 GDF-15 vial image

    Recombinant human GDF-15 protein (Qk017)

    £205.00 – £2,900.00
    View product This product has multiple variants. The options may be chosen on the product page

    Recombinant human TGF-β1 PLUS™ protein (Qk010)

    Recombinant human TGF-β1 PLUS™ protein (Qk010)

    The first commercially available animal origin-free TGF-β1

    £255.00 – £3,600.00
    View product This product has multiple variants. The options may be chosen on the product page

    Qk072 TGF beta 2 vial image

    Recombinant human TGF-β2 protein (Qk072)

    £255.00 – £3,600.00
    View product This product has multiple variants. The options may be chosen on the product page

    Qk054 TGF beta 3 vial image

    Recombinant human TGF-β3 protein (Qk054)

    £255.00 – £3,600.00
    View product This product has multiple variants. The options may be chosen on the product page

    Qk084 TGF beta 3 vial image

    Recombinant porcine TGF-β3 protein (Qk084)

    £255.00 – £3,600.00
    View product This product has multiple variants. The options may be chosen on the product page

    StemBeads® Qkine activin A

    StemBeads® Qkine activin A

    £175.00 – £240.00
    View product This product has multiple variants. The options may be chosen on the product page

    Qk108-FG vial image

    Recombinant bovine/porcine activin A protein (Qk108-FG)

    £205.00 – £2,900.00
    View product This product has multiple variants. The options may be chosen on the product page

    Qk109-FG vial image

    Recombinant bovine/porcine activin A PLUSâ„¢ protein (Qk109-FG)

    £155.00 – £2,300.00
    View product This product has multiple variants. The options may be chosen on the product page

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