TGF-β superfamily

Members of the TGF-beta superfamily, such as activins, TGF-beta 1, TGF-beta 2, TGF-beta 3, GDF-5, GDF-15, GDNF, and BMPs, play crucial roles in governing various developmental and physiological processes. These proteins contribute to the regulation of fundamental cellular properties and vital cellular processes, such as cell growth, differentiation, proliferation, survival, apoptosis, morphogenesis, and tissue remodeling.

Transforming growth factor beta superfamily encompasses a range of proteins including TGF-beta, Growth Differentiation Factors (GDFs), Bone Morphogenetic Proteins (BMPs), Glial-derived Neurotrophic Factors (GDNFs), Inhibins, activins, nodal, lefty, and Mülllerian Inhibiting Substance (MIS).

Shared among these members are dimeric structures and receptor complexes composed of both type I and type II receptor subunits, each containing serine/threonine kinase domains. Upon ligand binding, the type II receptor phosphorylates and activates the type I receptor, initiating a signaling cascade reliant on Smad proteins that ultimately regulates gene expression.

This superfamily of proteins plays diverse roles in  embryonic development, morphogenesis, adult stem cell differentiation, wound healing, immune regulation, cancer and inflammation.

Qkine robust animal-free manufacturing platform, along with rigorous quality control procedures, ensure that all our transforming growth factor beta proteins are:

  • animal origin-free (AOF) and carrier protein-free
  • highly pure (>98%, by SDS-PAGE quantitative densitometry)
  • highly bioactive (equally or more bioactive than other dominant suppliers) and come with our Bioactivity Guarantee
  • highly reproducible with excellent lot-to-lot consistency

Qkine is committed to manufacturing bioactive proteins of the highest quality to enhance scientific outcomes and improve reproducibility. All our products rigorously adhere to the Nine-point Qkine Quality Commitment.

Any questions? Contact us, our dedicated team of stem cell specialists is available to answer any queries you may have and to give expert support.

Home » TGF-β superfamily

TGF-β superfamily

    Vial image activin A

    Recombinant human activin A protein (Qk001)

    High purity and bioactivity animal origin-free recombinant activin A for highly reproducible stem cell culture.

    Price range: £230.00 through £2,900.00
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    Recombinant mouse/rat activin A protein (Qk012)

    Recombinant mouse/rat activin A protein (Qk012)

    High purity and bioactivity animal origin-free recombinant activin A for highly reproducible stem cell culture.

    Price range: £230.00 through £2,900.00
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    Vial image activin A PLUS

    Recombinant human activin A PLUS™ protein (Qk005)

    Optimized biologically active truncation of the mature domain of human activin A protein for cost-effective, large-scale stem cell culture applications.

    Price range: £175.00 through £2,300.00
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    Recombinant mouse/rat activin A PLUS™ protein (Qk014)

    Recombinant mouse/rat activin A PLUS™ protein (Qk014)

    Optimized biologically active truncation of the mature domain of human activin A protein for cost-effective, large-scale stem cell culture applications.

    Price range: £175.00 through £2,300.00
    View product This product has multiple variants. The options may be chosen on the product page

    Recombinant human follistatin-resistant activin A (FRACTA) protein (Qk035)

    Recombinant human follistatin-resistant activin A (FRACTA) protein (Qk035)

    Equivalent bioactivity to wild-type activin A, engineered to prevent binding to the natural activin A inhibitor follistatin, preventing feedback inhibition in cell cultures.

    Price range: £230.00 through £2,900.00
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    Recombinant human activin B protein (Qk024)

    Recombinant human activin B protein (Qk024)

    Price range: £290.00 through £3,600.00
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    Recombinant human activin C protein (Qk026)

    Recombinant human activin C protein (Qk026)

    Price range: £290.00 through £3,600.00
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    Vial image

    Recombinant human activin E PLUS™ protein (Qk067)

    Optimized biologically active truncation of the mature domain of human activin E protein, animal origin-free.

    Price range: £290.00 through £3,600.00
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    Vial image BMP-2

    Recombinant human BMP-2 protein (Qk007)

    Animal origin-free BMP-2 key regulator of embryogenesis and potent differentiation factor of embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) towards endoderm fates.

    Price range: £230.00 through £2,900.00
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    Qk038 BMP-4 vial image

    Recombinant human BMP-4 protein (Qk038)

    Highly pure animal origin-free protein, key regulator of embryogenesis and supports the differentiation of embryonic stem cells and induced pluripotent stem cells.

    Price range: £230.00 through £2,900.00
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    Qk070 GDF-5 vial image

    Recombinant human GDF-5 protein (Qk070)

    For the differentiation and maintenance of induced pluripotent stem cells, embryonic stem cells, or bone marrow-derived mesenchymal stem cells into osteoblasts and chondrocytes.

    Price range: £230.00 through £2,900.00
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    Qk017 GDF-15 vial image

    Recombinant human GDF-15 protein (Qk017)

    Exceptionally high purity, animal origin-free and extensively validated to ensure no trace contamination of related TGF-β family proteins from the mammalian culture systems.

    Price range: £230.00 through £2,900.00
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    Recombinant human TGF-β1 PLUS™ protein (Qk010)

    Recombinant human TGF-β1 PLUS™ protein (Qk010)

    The first commercially available animal origin-free TGF-β1

    Price range: £290.00 through £3,600.00
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    Qk072 TGF beta 2 vial image

    Recombinant human TGF-β2 protein (Qk072)

    High purity animal origin free protein, essential growth factor in many embryonic and induced pluripotent stem cell culture media.

    Price range: £290.00 through £3,600.00
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    Recombinant mouse TGF-β3 protein (Qk019)

    Recombinant mouse TGF-β3 protein (Qk019)

    Price range: £290.00 through £3,600.00
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    Qk054 TGF beta 3 vial image

    Recombinant human TGF-β3 protein (Qk054)

    Animal origin-free for reproducible pluripotent stem cell maintenance.

    Price range: £290.00 through £3,600.00
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    Qk084 TGF beta 3 vial image

    Recombinant porcine TGF-β3 protein (Qk084)

    Price range: £290.00 through £3,600.00
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    StemBeads® Qkine activin A

    StemBeads® Qkine activin A

    Price range: £175.00 through £240.00
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    Recombinant human activin A protein (Qk001-CTG)

    Recombinant human activin A protein (Qk001-CTG)

    High purity and bioactivity animal origin-free recombinant activin A for pluripotent stem cell therapy.

    Price range: £3,035.00 through £4,785.00
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    Recombinant human TGF-β1 PLUS™ protein (Qk010-CTG)

    Recombinant human TGF-β1 PLUS™ protein (Qk010-CTG)

    The first commercially available animal origin-free TGF-β1 for cell and gene therapy

    Price range: £5,060.00 through £7,920.00
    View product This product has multiple variants. The options may be chosen on the product page

    Recombinant human TGF-β3 protein (Qk054-CTG)

    Recombinant human TGF-β3 protein (Qk054-CTG)

    Animal origin-free highly bioactive cell therapy grade TGF-β3 for pluripotent stem cell therapies.

    Price range: £5,250.00 through £6,750.00
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