R-spondin family (RSPO)

R-spondin family (RSPO) plays essential roles in embryonic development and organ formation. Including 4 secreted glycoproteins (R-spondin 1, 2,3, 4), RSPO family is involved in the activation and regulation of the Wnt signaling pathway.

Our R-spondin range includes RSPO1 protein, the prototypic member of this family used to potentiate Wnt signaling in many organoid culture systems including intestinal and tumor (cancer) organoid culture. RSPO1 is also required for hematopoietic stem cell specification and cancer cell migration and survival.

We also developed a specialized form of RSPO1, R-spondin 1 LR5, engineered to act as a high affinity ligand for the LGR5 receptor. Our R-spondin family also includes Human RSPO3 protein which can be used alongside RSPO1 in intestinal organoid culture systems.

Qkine robust animal-free manufacturing platform, along with rigorous quality control procedures, ensure that all our r-spondin proteins are:

• animal origin-free (AOF) and carrier protein-free
• highly pure (>98%, by SDS-PAGE quantitative densitometry)
• highly bioactive (equally or more bioactive than other dominant suppliers) and come with our Bioactivity Guarantee
• highly reproducible with excellent lot-to-lot consistency

Qkine is committed to manufacturing bioactive proteins of the highest quality to enhance scientific outcomes and improve reproducibility. Our stringent quality control procedures in place ensure your results are reliable and reproducible every time.  We couple this with unrivaled lot-to-lot consistency, ensuring every single batch meets the same quality standards as all previous ones, thereby reducing the need for batch testing. All our products rigorously adhere to the Nine-point Qkine Quality Commitment.

Please contact us if you have any questions. Our dedicated team of stem cell specialists is available to answer any queries.