Human bone morphogenetic protein 4 (BMP-4) is a key regulator of embryogenesis and supports the differentiation of embryonic stem cells and induced pluripotent stem cells.
In addition, BMP-4 plays a role in the differentiation of mesenchymal cells to adipocytes, epithelial cancer EMT, and regulating neuronal and glial cell development.
Bone morphogenetic protein 4 has a complex biochemical structure. Special care and expertise is required to manufacture BMP-4 at high purity and with good lot consistency. Ensuring high bioactivity allows lower concentrations of growth factors to be used in media for cost-effective cell culture.