SB431542 (Qk1103)
Price range: £110.00 through £190.00
SB431542 is a potent and selective inhibitor of ALK4, ALK5 and ALK7 receptors which activate the TGF-β/activin/nodal pathway. This pathway is essential for maintaining pluripotency in embryonic (ESC) and induced pluripotent stem cells (iPSC). In cell culture, SB431542 can be used for induced differentiation of ESC and iPSC into mesenchymal lineages, cardiac and neural differentiation.
Qkine SB431542 (Qk1103) is highly pure and validated in iPSC differentiation into ectoderm.
In stock
Orders are typically shipped same or next day (except Friday).
Easy world-wide ordering, direct or through our distributors.
Price range: £110.00 through £190.00
Buy online with secure credit card or purchase order. For any questions, please email [email protected]
Summary:
- Cas No. 301836-41-9
- Molecular Weight: 384.4
Storage: powder -20°C for 1 year, in solvent -80°C for 1 year
Solubility EtOH 3.85 mg/ml, DMSO 48.5 mg/ml
Featured applications:
Differentiation of iPSC into ectoderm
Neural differentiation from pluripotent stem cells
Differentiation of induced pluripotent stem cells to astrocytes
Differentiation of midbrain dopaminergic neurons
Further quality assays
>99% purity
HPLC/HNMR: Consistent with structure
We are a company founded and run by scientists to provide a service and support innovation in stem cell biology and regenerative medicine. All our products are exceptionally high purity, with complete characterisation and bioactivity analysis on every lot.
Preparation of SB431542 stock solution in DMSO/EtOH
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.60 ml | 13.01 ml | 26.02 ml |
| 5 mM | 0.52 ml | 2.60 ml | 5.20 ml |
| 10 mM | 0.26 ml | 1.30 ml | 2.60 ml |
Product background
SB431542 is a potent and selective inhibitor of TGF-β type I Receptors ALK5 (IC50 = 94 nM) and ALK4 (IC50 = 140 nM) and ALK7 [1,2]. SB431542 does not have an effect on BMP, ERK, JNK, or p38 MAP kinase pathways or signaling pathways activated in response to serum [2]. TGF−β superfamily ligands including activins and nodal signal through these receptors, mediating essential cellular processes related to development, would healing and immune regulation [2, 3].
In embryonic stem cells (ESCs) activin/nodal signaling in combination with FGF-2 maintains pluripotency through the ALK4/5/7 receptor pathway, addition of SB431542 reduces expression of pluripotency marker Oct-4 [4]. SB431542 can also be used to induce differentiation of both ESCs and induced pluripotent stem cells (iPSCs) into mesenchymal stem cells (MSCs) [5]. As part of cell culture media, SB431542 enhances differentiation into neurons [6, 7], astrocytes and cardiomyocytes [7].
Additional resources
Our products are for research use only and not for diagnostic or therapeutic use. Products are not for resale.
For use in manufacturing of cellular or gene therapy products. Not intended for in vivo applications.
Receive a Qkine gift card when you leave us a review.
£100, $140 or €120 Qkine gift card for product reviews with an image and £50, $70 or €60 for reviews without an image.