Qkine and inscreenex collaborate to test cell models for drug discovery, disease modeling, and personalized medicine
The biotechnology company inscreenex is at the forefront of genetic engineering, delivering cutting-edge solutions for cellular research. Through its pioneering cell-type-specific immortalization technology, inscreenex empowers scientists to overcome the limitations of primary cell cultures, offering long-lasting and functional cell lines that are ideal for applications in drug discovery, disease modeling, and personalized medicine. This collaboration merges their expertise with that of Qkine in complex protein manufacturing and engineering to allow testing and validation of cell responses in disease modelling.
In recent studies, an inscreenex novel human alveolar epithelial cell line (ARLO) was used in an in vitro assay that examined the effects of three different isoforms of TGF-β; TGF-β1 (Qk010), TGF-β2 (Qk072) and TGF-β3 (Qk054). The results showed strong induction of key downstream markers of the TGF-β signaling pathways for all three isoforms. Interestingly, the induction factor and the effective concentration differed significantly. Therefore, this combination ARLO cell line and Qkine proteins will provide new insights into lung disease mechanisms and potential therapeutic interventions. This highlights ARLO’s value in fibrosis research and other TGF-β-mediated conditions.
TGF-β1 stimulated wound healing in lung cell lines huBroBEC and huArlo. After 72h 10 ng/ml TGF-β1 (TGFBQk1) stimulated wound healing after a scratch assay, compared to control (ctrl) with no TGF-β.
About Qkine: Qkine manufactures high-purity, animal origin-free growth factors, cytokines, and other complex proteins for life science applications including stem cell and organoid culture. Based in Cambridge, UK, Qkine combines proprietary production processes with protein engineering technology to tackle fundamental biological, quality and scale-up challenges to provide more reliable tools for research and bio-manufacturing. For more information, please visit www.qkine.com.
About inscreenex: With inscreenex, scientists gain access to a robust, scalable, and innovative platform that enables the creation of immortalized, functional cell lines across multiple research areas. Inscreenex technology represents the future of cellular research, driving advancements in science, medicine, and therapeutic development through reproducible, physiologically relevant, and highly customizable solutions.
