Pep Talk

July 2022

Growth factors are essential for replacing fetal bovine serum (FBS) in media for ethical and scalable culture of stem cells for applications requiring highly reproducible culture conditions. This is especially true for iPSC and organoid based regenerative medicines. As these progress towards the clinic, we need to provide evidence for a GMP-compliant cell manufacture process. However, there is a lack of clarity when defining GMP-compliance for ancillary (raw) materials, such as growth factors. We’ll be exploring this topic further on Linkedin this month, please join us.

Best regards,
Catherine (CEO and Founder)


hPSC directed differentiation

Download our latest infographic on directed differentiation of human pluripotent stem cells (hPSCs) towards specific cell types. This overview depicts the growth factors required to derive different cell types from hPSCs, with all methods corresponding to published work on human cells.

Human organoids review article

This review article was published in Nature earlier this year by Tang et al. Learn more about human organoids in basic research and clinical applications, and how human 3D organoid systems can be used to study both human physiology and developmental stages.

Tech tip of the month

Our tech tip this month is on reconstituting TGF beta family proteins. Always use a low pH (for example, 10mM HCl) as they will precipitate in physiological buffer. The low pH aids the maintenance of the correct disulphide structure by minimising disulphide bond exchange reactions.


This month we’ll be exhibiting at the Babraham institute in Cambridge, at 3DbioNet in Oxford, and at Pan3DP conference in London. To see full details of the events, please visit our news section.

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