Qk006: R-spondin-1 (human)


Receptor-binding active domain of human R-spondin 1 (Uniprot: Q2MKA7) comprising two furin-like domains expressed in E.coli and purified to homogeneity.
Protein is lyophilised (carrier protein-free)


R-spondin 1 (Rspo 1) – Uniprot: Q2MKA7 – is a secreted activator of the canonical Wnt signaling pathway used extensively in adult stem cell-derived organoid culture, hematopoietic stem cell specification and other iPSC and culture systems.

Highly pure biologically active protein comprising the two cysteine-rich, furin-like domains, the essential domains for activity in stem cell culture.  Expressed in E.coli, for optimised reliable production of homogeneous protein and enhanced comparability between batches.

Protein is supplied lyophilised (carrier protein-free)

Please visit our R-spondin protein page for full details and batch specific data.

We take the quality of our products very seriously. All our proteins are produced in-house by our scientists and we understand the potential impact on your work if your growth factors and cytokines are not consistent and of the highest quality.  We provide comprehensive quality data for every batch.

Please contact Meena at orders@qkine.com for batch reservation, bulk purchasing arrangements or any other questions.

Additional information

Unit size

1000 µg, 500 µg, 100 µg, 50 µg, 25 µg

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  1. Dennis Plenker, Tuveson Lab, CSHL

    Recombinant R-spondin-1 replaces R-spondin-1 conditioned media in pancreatic tumor organoid culture

    Admin Dennis Plenker, Tuveson Lab, CSHL

    Comparison of pancreatic organoid growth over three passages.

    P-0 indicates the initial start of the culture in full growth media supplemented with Wnt3a and R-spondin-1-conditioned media.  For the recombinant (rec.) R-spondin-1 and no R-spondin-1 conditions full growth media was depleted of R-spondin-1 conditioned media and supplemented with rec. R-spondin-1 or without R-spondin-1.  No differences in organoid growth have been observed when using recombinant R-spondin-1 instead of R-spondin-1-conditioned media.  Experiments have been conducted by Dennis Plenker, Ph.D. in the lab of Dr David Tuveson at Cold Spring Harbor Laboratory.

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