Recombinant human GDF-15 (Qk017)

£240.00£2,400.00

Mature domain of recombinant human GDF15 protein (Uniprot: Q99988) expressed in E.coli.  No contaminating TGF beta family growth factors.
Protein is lyophilised (carrier protein-free).

Datasheets

Batch-specific datasheets

SKU: Qk017_hGDF15 Category: Tags: , , ,

Description

Growth/differentiation factor 15 (GDF15) is a distant member of the TGFβ superfamily. Its expression is tightly regulated and circulating GDF15 in serum is associated with diseases such as cancer, cardiovascular disease, obesity and metabolic disease.

Unlike other members of the TGFβ superfamily that cause activation of the SMAD pathway, GDF15 signals through GRAL and co-receptor RET leading to RET phosphorylation and signalling through the ERK and AKT pathway (reviewed in Emmerson et al., 2018).  Commercial sources of GDF15, in particular those purified from mammalian expression are frequently contaminated with trace amounts of TGFβ and related proteins. These trace contaminants cause misleading experimental results due to the picomolar or even femtomolar EC50s of this family of cytokines (2).

We produce our proteins in E.coli with no animal products in our culture or purification processes to ensure there is no contamination from related proteins. In addition, we use a well-characterised SMAD2/3 activation assay to confirm there is no SMAD signalling.

Mature domain of human GDF15 (Uniprot: Q99988) expressed in E.coli and purified to homogeneity

Protein is lyophilised (carrier protein free).

Please visit our GDF15 protein page for full details and batch specific data.

We take the quality of our products very seriously. All our proteins are produced in-house by our scientists and we understand the potential impact on your work if your growth factors and cytokines are not consistent and of the highest quality.  We provide comprehensive quality data for every batch.

Additional information

Unit size

1000 µg, 500 µg, 100 µg, 50 µg

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