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Qk005 Activin A PLUS (human) Qkine protein vial
recombinant human/mouse/rat Activin A PLUS (Qk005)£120.00£1,900.00

Human/mouse/rat activin A PLUS protein is an optimised biologically active truncation of the mature domain of human Activin A protein.  The EC50 and activity in stem cell culture of activin A PLUS is equivalent to the full mature domain activin A.

High purity 24 kDa dimer comprising truncated mature domain of activin A protein, animal-free (AF) and carrier-protein free (CF).  Recombinant activin A PLUS is designed to be manufactured at scale for cost-effective, large-scale stem cell culture applications.

Show detailsipsc-esc-differentiation ipsc-esc-maintenance optimised-by-qkine
Qk038-BMP4-human-qkine-vial
recombinant human BMP-4 protein (Qk038)£200.00£3,000.00

Human BMP4 (bone morphogenetic protein 4) protein is a key regulator of embryogenesis and supports the differentiation of embryonic stem cells and induced pluripotent stem cells. In addition, BMP4 plays roles in the differentiation of mesenchymal cells to adipocytes, epithelial cancer EMT, and regulating neuronal and glial cell development.

Highly pure 26 kDa disulfide–linked bioactive dimer comprised of the mature domain of human BMP4 protein (animal-free and carrier protein-free).

Show detailsipsc-esc-differentiation bmp4 bmps epithelial human ipsc-esc-maintenance mesenchymal neural organoid
Qk025 FGF2 / bFGF (human) Qkine protein vial
recombinant human FGF-2 / bFGF protein (145 aa) (Qk025)£100.00£600.00

Human FGF2 /bFGF protein (145 aa) is our gold-standard and recommended FGF2 / bFGF protein for induced pluripotent stem cell (iPSC) and embryonic stem cells (ESC) maintenance, and induced pluripotent and mesenchymal stem cells proliferation and differentiation.

High purity and bioactivity 17 kDa FGF2 / bFGF protein, animal-derived component free (ACDF) and carrier-protein free (CF) comprising the core structured region (145 amino acids) sufficient for full biological activity.

Show detailsipsc-esc-differentiation fgfs human ipsc-esc-maintenance organoid
Qk027 FGF2 / bFGF (human) Qkine protein vial
recombinant human FGF-2 /bFGF protein (154 aa) (Qk027)£100.00£600.00

Human FGF2 / bFGF protein (154 aa) is a highly bioactive, long–form of human fibroblast growth factor 2 protein.   Human bFGF / FGF-2 protein is used to support the maintenance of human embryonic stem cells and proliferation and differentiation of induced pluripotent and mesenchymal stem cells. This 154 aa form of FGF2 comprises the core structured region and N-terminal extension.

High purity and bioactivity 17 kDa FGF2 / bFGF protein, animal-derived component free (ACDF) and carrier-protein free (CF).

Show detailsipsc-esc-differentiation fgfs human ipsc-esc-maintenance organoid
recombinant mouse FGF-2 (bFGF) protein (Qk042)
recombinant mouse FGF-2 (bFGF) protein (Qk042)£100.00£600.00

mouse FGF2 / bFGF protein is an important factor in the maintenance of mouse epiblast-derived stem cells (EpiSC). Mouse naïve pluripotency is maintained by LIF, BMP4, and Wnt signalling pathways. However, the primed state of pluripotency in mouse EpiSCs is more similar to hESC and hiPSC, being maintained by FGF2 and TGFβ/Activin/Nodal pathways.1,2

High purity and bioactivity 16 kDa murine bFGF / FGF2 (basic FGF) protein, animal-origin free (AOF) and carrier-protein free (CF).

Show detailsipsc-esc-differentiation fgfs ipsc-esc-maintenance mouse mouse-es-cell organoid
recombinant human IGF-1 LR3 protein (Qk041)
recombinant human IGF-1 LR3 protein (Qk041)£50.00£175.00

Human IGF-1 LR3, insulin-like growth factor long arginine 3, protein is a synthetic form of IGF-1 with an N-terminal protein extension that improves potency and metabolic stability. IGF-1 LR3 is often used in the maintenance of human pluripotent stem cells1

Highly pure and bioactive 9 kDa IGR-1 LR3 protein monomer, animal-free (AF) and carrier-protein free (CF)

Show detailsepithelial hematopoietic human igf ipsc-esc-maintenance neural
Qk036-LIF-human-qkine-vial
recombinant human LIF protein (Qk036)£120.00£1,600.00

Human LIF (leukemia inhibitory factor) protein suppresses the differentiation of embryonic stem cells (ESCs) and is widely used in ESC and iPSC culture (1).  Human LIF can be used in the maintenance of both murine and human ESCs in feeder or feeder-free chemically defined culture systems (2)

LIF is a pleiotrophic factor that belongs to the IL-6 superfamily of cytokines. Acting through a heterodimeric receptor of gp130 and gp190, LIF can activate a number of cellular pathways including the JAK/STAT, PI3K and MAPK pathways (3).

Qkine human LIF protein is high purity and animal and carrier-protein free for reproducible results.

Show detailshuman ipsc-esc-maintenance lifs mouse-es-cell neural
Qk018 LIF (mouse) Qkine protein vial
recombinant mouse LIF protein (Qk018)£120.00£1,600.00

Mouse LIF (murine leukemia inhibitory factor) protein supports the derivation, propagation and expansion of mouse embryonic stem cells (ESC), and maintenance of pluripotency.   LIF protein increases the robustness of mouse embryonic stem cell culture in feeder or feeder-free chemically defined culture systems.

Qkine recombinant mouse LIF protein is animal-free and carrier-protein free for highly reproducible results. Bioactivity was tested by colony formation assay and determination of Nanog expression (1).

 

 

Show detailsipsc-esc-maintenance lifs mouse mouse-es-cell
Qk034-Noggin-human-qkine-vial
recombinant human noggin protein (Qk034)£160.00£2,400.00

Human noggin supports growth of organoids derived from epithelial tissues and iPSC and ESC differentiation. Noggin protein is a bone morphogenetic protein (BMP) family antagonist used in the culture of intestinal, pancreatic, lung and tumor-derived organoids; epithelial organoid culture (WNR media), maintenance of undifferentiated embryonic stem cells and for stem cell differentiation into neural and microglial lineages.

Qkine human noggin protein is a highly pure 46kDa bioactive dimer for reproducible results in organoid culture.

Show detailsipsc-esc-differentiation bmps human ipsc-esc-maintenance mouse-es-cell neural noggins organoid
Qk033 Noggin (mouse) Qkine protein vial
recombinant mouse/rat Noggin protein (Qk033)£160.00£2,400.00

Mouse/rat noggin supports growth of organoids derived from mouse epithelial tissues and stem cell differentiation. Noggin protein is a bone morphogenetic protein (BMP) family antagonist used in the culture of intestinal, pancreatic, lung and tumor-derived organoids; maintenance of embryonic stem cells and differentiation into neural lineages.

Qkine recombinant mouse noggin protein is a highly pure 46kDa bioactive dimer for reproducible results (animal-free and carrier-protein free).

Show detailsipsc-esc-differentiation bmps epithelial ipsc-esc-maintenance mouse mouse-es-cell neural noggins organoid rat
Qk006 R-spondin 1 (human) Qkine protein vial
recombinant human R-spondin 1 protein (Qk006)£120.00£1,600.00

Human R-spondin 1 protein (RSPO1) is the prototypic member of the R-spondin family and is used to potentiate Wnt signalling in many organoid culture systems including intestinal and tumor (cancer) organoid culture. R-spondin 1 is also required for hematopoietic stem cell specification and cancer cell migration and survival.

13kDa highly pure, bioactive domain of human R-spondin 1 comprising the two cysteine-rich furin-like domains of R-spondin 1, which are necessary and sufficient for Wnt signalling potentiation and are the essential domains for activity in stem cell and organoid culture.  Qk006 is animal-free and not glycosylated to ensure production of homogeneous protein and enhanced comparability between batches. Used to replace R-spondin conditioned media for improved reproducibility in chemically defined organoid culture media.

Show detailsipsc-esc-differentiation human ipsc-esc-maintenance optimised-by-qkine organoid r-spondins
Qk031 R-spondin 1 LR5 vial)
recombinant human R-spondin 1 LR5 protein (Qk031)£120.00£180.00

Recombinant R-spondin 1 LR5 protein is engineered to act as a high affinity ligand for the LGR5 receptor.  In epithelial tissues LGR5 marks the stem cell population.  This engineered protein, R-spondin 1 LR5, activates wnt signalling only in the LGR5+ stem cell population.  R-spondin1 LR5 has been tested in intestinal organoid culture and supports organoid survival and growth. As LGR5 specifically marks stem cells and is not found on transit amplifying cells, the lower crypt multiplicity seen in organoid cultures with R-spondin 1 LR5 (in comparison to wild-type R-spondin 1, Qk006) supports the notion that this engineered form is acting specifically on stem cells.  This specialized form of R-spondin 1 was developed in Marc de la Roche’s lab (University of Cambridge).

Show detailsipsc-esc-differentiation ipsc-esc-maintenance optimised-by-qkine organoid pioneering-proteins r-spondins
Qk018 TGF beta 1 PLUS (human) Qkine protein vial
recombinant human/bovine/porcine TGF-β1 PLUS protein (Qk010)£200.00£3,000.00

Human/bovine/porcine TGF-β1 PLUS protein is the first entirely animal-free recombinant human transforming growth factor beta 1 (TGF-β1) protein for highly reproducible results and compatible with chemically-defined stem cell media. TGFβ1 is used extensively in E8-style induced pluripotent (iPSC) and embryonic (ESC) stem cell media.

High purity 24 kDa dimer comprising optimised mature domain of TGFβ1 protein, animal-free (AF) and carrier-protein free (CF).  Our  TGF-β1 PLUS protein has been extensively tested for maintenance of iPSC pluripotency by the specialist stem cell biotechnology company, Stemnovate, Cambridge, UK.

*Benchmark our TGF-β1 PLUS against your existing supplier*

Show detailsbovine human ipsc-esc-maintenance optimised-by-qkine porcine

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