|recombinant human/mouse/rat/bovine/porcine activin A protein (Qk001)||£160.00 – £2,400.00|
Human/mouse/rat/bovine/porcine activin A protein is a TGFβ family growth factor used frequently for the maintenance of pluripotency in induced pluripotent stem cell (iPSC) and embryonic stem cell (ESC) culture. Activin A is also used in many stem cell differentiation protocols, including for directed differentiation into endoderm lineages such as hepatocyte and pancreatic cells. This protein has been extensively validated for highly reproducible stem cell culture. Qkine founder, Marko Hyvönen, developed the protocol for making high purity activin A and this protein is used at the Cambridge Stem Cell Institute.
High purity mature bioactive dimer. Animal-free (AOF) and carrier-protein free (CF). Rigorously benchmarked against other commercial sources.
|Show details||growth-factor-cytokine activin-proteins bovine cellular-agriculture hepatocyte ipsc-esc-maintenance tgf-beta-family|
|recombinant human/mouse/rat/bovine/porcine BMP-2 protein (Qk007)||£160.00 – £2,400.00|
Human/mouse/rat/bovine/porcine BMP-2 protein (bone morphogenetic protein 2) protein is member of the TGFβ family and a key regulator of embryogenesis and potent differentiation factor of embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) towards endoderm fates. BMP-2 plays roles in the differentiation of mesenchymal cells to adipocytes, epithelial cancer EMT, chondrogenesis and regulation of neuronal and glial cell development.
26 kDa disulfide–linked bioactive highly pure dimer comprised of the mature domain of human BMP-2 protein. Animal-free (AOF) and carrier protein-free.
|Show details||growth-factor-cytokine bmp-family bovine human mouse porcine rat|
|recombinant FGF2-G3 protein (Qk053)||£120.00 – £3,000.00|
FGF2-G3 (FGF2-STAB®) protein is a thermostable engineered form of FGF-2 (bFGF). Qk053 is the 154 aa mature domain of FGF-2 (Qk027) with nine amino acid substitutions to enhance stability without impacting bioactivity developed by Dvorak et al. 2018. This increases the functional half-life of the protein from <10 h (wild-type) to >7 days (FGF2-G3).
FGF2-G3 is used in B8 media (Kuo et al. 2019) for weekend free, high homogeneity induced pluripotent stem cell culture. FGF2-G3 also has applications in chemically defined stem cell and organoid culture media, and cultured meat media development.
High purity 17 kDa bioactive FGF2-G3 protein. Animal-free (AOF), carrier protein-free and with no His-tag.
|Show details||growth-factor-cytokine bovine fgf-family human mouse optimised-by-qkine porcine rat|
|recombinant bovine/porcine FGF-2 (bFGF) protein (Qk040)||£100.00 – £600.00|
Bovine/porcine FGF2 protein (bFGF/basic FGF) for development of species specific bovine (cow) and porcine (pig) cellular agriculture protocols and veterinary research applications.
FGF-2 is used extensively in maintenance and proliferation of induced pluripotent (iPSC) and embryonic stem cells (ESC)1-3 and for enhancement of proliferation in primary cell culture.
High purity 16 kDa FGF-2 / bFGF protein, animal-derived component free (ACDF) and carrier-protein free (CF).
|Show details||growth-factor-cytokine bovine cellular-agriculture fgf-family ipsc-esc-maintenance organoid porcine|
|recombinant human/rat/bovine/porcine FGF-10 protein (Qk003)||£160.00 – £1,200.00|
Human/rat/porcine/bovine FGF10 protein promotes lung organoid formation and induces branching morphology. FGF10 protein is used widely in organoid culture, embryonic stem cell (ESC) and induced-pluripotent stem cell (iPSC) differentiation, and for the study of epithelial to mesenchymal transition and tumor metastasis.
High purity and bioactivity 17 kDa non-glycosylated, bioactive domain of human fibroblast growth factor 10, animal-derived component free (ACDF) and carrier-protein free (CF).
|Show details||growth-factor-cytokine bovine fgf-family hepatocyte human organoid porcine rat|
|recombinant human/bovine/porcine Gremlin 1 protein (Qk015)||£100.00 – £1,200.00|
Human/bovine/porcine Gremlin 1 protein is a BMP-inhibitor present in the natural intestinal niche and provides an alternative to Noggin for optimisation of intestinal organoid culture and iPSC differentiation.
Qk015 has been optimized by our experts for exceptionally high-purity production in E.coli and bioactivity. 18 kDa high purity dimeric protein, animal-free and carrier protein free
|Show details||growth-factor-cytokine bmp-family bovine human ipsc-esc-maintenance optimised-by-qkine organoid porcine|
|recombinant human/bovine/porcine NRG-1 protein (Qk045)||£100.00 – £1,200.00|
Human NRG-1 (Neuregulin 1) protein is frequently used in the maintenance of human pluripotent stem cells. In addition to its widespread use in stem cell culture media, NRG-1 (also known as Heregulin-β1 , HRG-1) has essential roles in vivo including in nervous system, cardiac, and mammary gland development; cancer biology and neurological disorders.
7.5 kDa highly pure, bioactive domain of human NRG-1, comprised of the β isoform of the EGF-like domain of NRG-1 (HRG1-B1). This NRG-1 protein monomer is animal-free (AF) and carrier-protein free (CF).
|Show details||bovine cellular-agriculture egf-family human ipsc-esc-maintenance neural porcine|
|recombinant human/bovine/porcine TGF-β1 PLUS protein (Qk010)||£200.00 – £3,000.00|
Human/bovine/porcine TGF-β1 PLUS protein is the first entirely animal-free recombinant human transforming growth factor beta 1 (TGF-β1) protein for highly reproducible results and compatible with chemically-defined stem cell media. TGFβ1 is used extensively in E8-style induced pluripotent (iPSC) and embryonic (ESC) stem cell media.
High purity 24 kDa dimer comprising optimised mature domain of TGFβ1 protein, animal-free (AF) and carrier-protein free (CF). Our TGF-β1 PLUS protein has been extensively tested for maintenance of iPSC pluripotency by the specialist stem cell biotechnology company, Stemnovate, Cambridge, UK.
*Benchmark our TGF-β1 PLUS against your existing supplier*
|Show details||bovine human ipsc-esc-maintenance optimised-by-qkine porcine|