Recombinant human Activin A Plus protein is a high purity, animal-free 24 kDa biologically active truncation of the mature domain of human Activin A protein. Our recombinant Activin A PLUS is designed to be manufactured at scale for cost-effective large-scale stem cell culture applications. 

Recombinant human Activin A protein is a 26 kDa disulfide-linked dimer composed of the mature active domain of human Activin A protein. Our Activin A protein has been extensively validated for its reproducibility in stem cell culture, and benchmarked against other commercial sources.

Recombinant human BMP2 protein is a 26 kDa disulfide–linked bioactive dimer comprised of the mature domain of human BMP2 protein. Our recombinant human BMP2 protein has been optimized for expression in E. coli and purified to homogeneity, offering a highly reliable and cost-effective option for the regulation of stem cell differentiation.

Recombinant human EGF protein is a 6.3 kDa biologically active domain of human epidermal growth factor. Our recombinant EGF protein is expressed to the highest purity in E. coli and extensively tested, making it ideal for use in chemically-defined iPSC, ESC and organoid culture media. 

Recombinant human FGF10 protein is a 17 kDa non-glycosylated, bioactive domain of human fibroblast growth factor 10. Our high-purity FGF10 protein is produced in E. coli and purified to homogeneity. For use in organoid culture, ESC/iPSC differentiation, and for the study of epithelial to mesenchymal transition and tumor metastasis. 

Recombinant human FGF2 /bFGF protein (145 aa) is a highly bioactive, short–form variant of human fibroblast growth factor 2 protein. Our high-purity FGF2 protein is a reliable option for ES cell and iPSC maintenance, as well as iPSC/MSC proliferation and differentiation.

Recombinant human FGF2 / bFGF protein (154 aa) is a highly bioactive, long–form variant of human fibroblast growth factor 2 protein. Our recombinant FGF2 protein has been optimized for high-purity expression in E. coli, making it a reliable option for the regulation of ESC maintenance, as well as iPSC/MSC proliferation and differentiation.

Recombinant human FGF4 protein is a 14 kDa non-glycosylated, high purity, bioactive domain of human fibroblast growth factor 4 expressed in E. coli. For the proliferation and differentiation of embryonic and tissue stem cells and organoid culture. 

Recombinant human GDF15 (growth differentiation factor 15) protein is a 25 kDa disulfide-linked dimer composed of the mature domain of human growth differentiation factor 15 protein. Our recombinant GDF15 protein is expressed in E. coli and extensively validated to ensure no trace contamination of TGFβ, which can cause misleading results. 

Animal-derived component and carrier protein-free

Recombinant human Gremlin 1 protein has been optimized by our experts for exceptionally high-purity production and bioactivity.   Gremlin-1 is a BMP-inhibitor present in the natural intestinal niche and provides an animal-free substitute for Noggin in chemically-defined media for many ESC, iPSC and organoid culture systems. 

Recombinant human HGF (NK1) protein is a high purity NK1 isoform of human hepatocyte growth factor (HGF) that promotes efficient differentiation of human iPSCs to hepatocyte-like cells at just 10 ng/ml with highly homogeneous expression of the hepatic marker, HNF4α.  The highly scalable animal-free manufacture and enhanced bioactivity make this suitable for chemically-defined media and reproducible scale-up.

Recombinant human Noggin supports growth of organoids derived from epithelial tissues and iPSC and ESC differentiation. Noggin protein is a bone morphogenetic protein (BMP) family antagonist used in the culture of intestinal, pancreatic, lung and tumor-derived organoids; maintenance of embryonic stem cells and differentiation into neural lineages. Qkine recombinant human noggin protein is animal and carrier-protein free for highly reproducible results and use in chemically defined media.

Recombinant human R-spondin 1 protein (RSPO1) is a 13kDa highly pure, bioactive fragment of human R-spondin 1. Our recombinant human R-spondin 1 protein is animal-free and not glycosylated to ensure production of homogeneous protein and enhanced comparability between batches.

Recombinant human R-spondin 3 protein is a 17 kDa bioactive fragment of human R-spondin 3 protein comprised of the two cysteine-rich furin-like domains, which are essential for its activity in stem cell and organoid culture. Our recombinant R-spondin 3 has been purified to homogeneity and is animal-free to ensure batch to batch consistency when adding to chemically-defined culture media.

Recombinant human TGF-β1 PLUS protein is the first entirely animal-free recombinant human transforming growth factor beta 1 (TGF-β1) protein for highly reproducible results and compatible with chemically-defined stem cell media. Our  TGF-β1 PLUS protein has been extensively tested for maintenance of iPSC pluripotency by the specialist stem cell biotechnology company, Stemnovate, Cambridge, UK.

*Benchmark our TGF-β1 PLUS against your existing supplier*

Recombinant mouse LIF (murine leukemia inhibitory factor) protein supports the derivation, propagation and expansion of mouse embryonic stem cells (ESC), and maintenance of pluripotency. Qkine recombinant mouse LIF protein is animal and carrier-protein free for highly reproducible results. Bioactivity was tested by colony formation assay and determination of Nanog expression (1).

Recombinant mouse Noggin supports growth of organoids derived from mouse epithelial tissues and stem cell differentiation. Noggin protein is a bone morphogenetic protein (BMP) family antagonist used in the culture of intestinal, pancreatic, lung and tumor-derived organoids; maintenance of embryonic stem cells and differentiation into neural lineages. Qkine recombinant mouse noggin protein is animal and carrier-protein free for highly reproducible results and use in chemically defined media.

Recombinant zebrafish FGF2 protein (bFGF) is a 17 kDa biologically active domain of zebrafish fibroblast growth factor 2 protein, expressed in E. coli and purified to homogeneity. Our recombinant FGF2 protein is trusted by the Cambridge Stem Cell Institute, UK  to support the maintenance and differentiation of their stem cell cultures.